3434 results
Primary objective:To evaluate the clinical efficacy and side effects (adverse events) of a single dose stereotactic radiotherapy on the electro-anatomical arrhythmia substrate, inaccessible by the current state of the art catheter ablation…
Primary objective: to assess the relation of an ex vivo functional assay for tumor radiosensitivity with clinical tumor response of OPC patients treated with (chemo/bio-)radiotherapy at 3 months after treatment.Secondary objectives: - to assess the…
The aim is to develop a method that can be used to determine, already in the ambulance, whether a patient suffers a stroke and if so, what the cause of stroke is. In this project we want to develop nanotechnology that is capable of detecting…
The primary objective of this study is to generate reference values for NFMS parameters as well as for 2D-STE parameters during the second trimester, 16 until 28 weeks gestational age. The secondary objective is to investigate the diagnostic…
Objectives: The primary objectives of this study are: • Part 1 (dose-escalation): To evaluate the safety of SYD985 in combination with niraparib to determine the maximum tolerated dose (MTD) and recommended combination dose regimen for expansion (…
The aim of this study is to better understand various prerequisites for the development, implementation, and immunological monitoring of immune regulation restoring therapies in RA patients. To meet this aim, the study is divided into four equally…
This study has been transitioned to CTIS with ID 2024-516427-13-00 check the CTIS register for the current data. Substudy A: The primary objective will be to investigate the relationships between HPA axis dysfunction, early life adversity (ELA), and…
We aim to provide a neurocognitive account of communicative disabilities in patients with autism spectrum disorder (ASD), focussing on shared representations of a communicative context. We expect that ASD patients show impaired shared…
To study the effect of voxelotor on the hemodynamics of the cerebral vasculature (CBF and CVR)
The overall objectives of the study are to evaluate the safety and efficacy (anatomical and functional visual outcomes) of two doses of GT005 in genetically defined subjects with GA due to AMD.
Our study aim is to assess whether it is feasible to remove small breast cancers completely using VAB under US guidance.
The goal of this study is to directly compare effectiveness of the Captain Morgan technique to the Allis technique in reduction of posterior dislocation of a THP using procedural sedation and analgesia (PSA) in the ER.
This study has been transitioned to CTIS with ID 2023-505261-84-00 check the CTIS register for the current data. The primary objective of this study is to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves…
The purpose of this study is to see if Crinecerfont is effective in reducing daily glucocorticoid dosage while maintaining adrenal androgen control.The purpose of the study is also to see if Crinecerfont is effective in reducing adrenal steroid…
To evaluate if an individualized antithrombotic P2Y12-inhibitor monotherapy in comparison to an individualized DAPT treatment is superior regarding bleeding events and non-inferior regarding ischemic events in patient with CCS after PCI.
This study has been transitioned to CTIS with ID 2023-510537-28-00 check the CTIS register for the current data. Primary:To compare the efficacy of BM in combination with BOR/DEX with that of daratumumab in combination with BOR/DEX in participants…
The main goal of this project is to investigate whether the oncologic outcome in patients with post-prostatectomy recurrent PCa can be improved, by increasing the biological effective radiation dose using a hypofractionated schedule of 20 x 3 = 60…
This study will be done to gain insights in the effects of A2 milk on GI symptoms, and immune and defense parameters, in IBS patients. The information will gain more insights in the working mechanism of different types of beta-casein in individuals…
The primary goal is to gain insight into the SARS-CoV-2 antibody response and its persistence (response dynamics) in healthcare workers with and without a proven COVID-19 infection by evaluating specific serological tests in the blood of healthcare…
To evaluate in SSc patients with low risk for disease progression 1) whether assessment in an outpatient clinic setting is an acceptable alternative for evaluation in the Care Pathway. Outcome parameters we will evaluate include 1) health care…