3434 results
Primary:- To evaluate the safety and tolerability of NT-0167 in healthy volunteersSecondary:- To evaluate the pharmacokinetic (PK) profile of NT-0167 in healthy volunteers after the administration of single ascending (SAD) and multiple ascending…
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The aim of the current study is to examine whether it is possible to improve speech recognition in specific CI users by optimizing dynamic range and mean aided thresholds. Furthermore, we want to investigate to what extent patient counselling and…
Primary Objective: 1.1 Does treatment according to the Dutch EMDR protocol for Urge reduce scratching behavior in AD patients? Hypothesis:1.1 H1: Treatment according to the Dutch EMDR protocol for Body Focused Repetitive Behavior , version…
1. To investigate esophageal sensitivity to acid infusion and balloon distension in eosinophilic esophagitis patients with histological active disease and disease in remission, as compared to healthy controls 2. To investigate the difference in…
The primary objective of the study is to investigate whether CRT reduces subjective cognitive symptoms. It is hypothesized that there is a significant improvement in subjective cognitive symptoms as measured by the Cognitive Failure Questionnaire (…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
This study will evaluate the RESET self-stigma reduction intervention: a face to face group workshop for PLHIV in the Netherlands that aims to reduce HIV-related self-stigma and improve wellbeing, specifically quality of life, self-esteem, resilient…
Primary Objective: • To evaluate the ability to concentrate the radiotracer in prostatic cancer lesions ( with respect to accumulation in background tissues) by prostatic artery injection (PAI), especially within the prostate gland compared to…
This study has been transitioned to CTIS with ID 2024-512824-13-01 check the CTIS register for the current data. The overarching goal of this study is to improve adequate resection of oral cancer. We will perform a clinical trial to determine the…
The purpose of this study is to investigate how quickly and to what extent PF-06835919 is absorbed and eliminated from the body.PF-06835919 will be labelled with Carbon-14 (14C) and is thus radioactive. In this way, PF-06835919 can be traced in…
Implementation of liquid biopsy by NGS in cell-free circulating tumor DNA in CSF and / or blood, in patients clinically suspected of leptomeningeal metastases and / or brain metastasesDemonstrate that the detection of additional tumor mutations in…
Primary Safety Objective: To describe the safety profile of 20vPnC
In this study, the objective is to examine the effect of protocolled cognitive behavioural therapy for insomnia (CBT-I) in adolescents with complex psychiatric problems and sleeping problems (problems falling asleep, staying asleep and/or waking up…
Primary objective: To evaluate the long-term safety and tolerability of BIIB078 in participants with C9ORF72-ALS.Secondary objective: To evaluate the PK of BIIB078 in participants with C9ORF72-ALS.Exploratory objectives:- To evaluate the PD of…
The objective of this study is:- to estimate the electrical conductivity of the chronic stroke lesion and the variance on this within chronic stroke subjectsSecondary:- derive functional organisation of the motor system of the upper extremity…
The purpose of this study is to investigate how quickly and to what extent BI 1358894 is absorbed and eliminated from the body (this is called pharmacokinetics) when given as a single dose / multiple doses. BI 1348894 will be labelled with Carbon-14…
Our objective is to study confidence abnormalities in OCD. We want to study:1) Confidence abnormalitites in a symptom-related versus a neutral context,2) Llearning-confidence coupling in a volatile environment in OCD,3) Metacognitive monitoring (i.e…
To design an industry-sponsored surveillance study incorporating both additional and existing materials that has the possibility of identifying trends in the incidence of skin contact allergy.
Primary research goal- Evaluate whether resuming activities of hairdressers and catering staff results in a significantly higher percentage that produces antibodies against SARS-CoV-2 after 3 months.Secondary research goals- Identifying determinants…