3434 results
To determine changes in brain activity in responses to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners.
Primary: to determine the loss of corneal endothelial cells after implantation of a Paul GDD with its tube either anterior or posterior of the iris. Secondary: to compare efficacy and safety of both procedures.
In this study we will investigate how safe the new compound Ent001 is and how well it is tolerated when it is used by healthy subjects.We also investigate how quickly and to what extent Ent001 is absorbed, transported, and eliminated from the body (…
Objective: The primary objective of this pilot project is to investigate the early course of motor development in children with DS. Secondary objectives are to investigate the relation between type of SCN1A mutation and developmental profile and to…
To assess the early predictive value of IUS for therapy response in children with IBD (new onset or known IBD).
In this study, we will investigate how quickly and to what extent the new compound PTC857 is absorbed, metabolized, and eliminated from the body. Both unlabeled and radioactively labeled PTC857 will be administered. Unlabeled PTC857 will be given…
Our overall aim is to measure several distinct MR parameters at 0.064 Tesla, and to use these to derive optimal MRI-protocols in terms of contrast and SNR. Some of these new developments may subsequently be used in clinical research protocols (which…
The study aims to determine the effectiveness of the application of AET in decreasing self-reported deficits in autonomy-connectedness / self-reported symptoms of anxiety and depression in HI adults.
The main objective of this study is to investigate sex and gender differences in the prospective relationship between experienced stressors, craving and alcohol use during treatment and early recovery of AUD. The secondary objectives of this study…
The main objective of this study is to assess the effectiveness of an integrated program of fitting and training interventions aimed at reducing unexpected variability and addressing the specific error patterns of each recipient.
Comparing different ventilation strategies in focal and non-focal ARDS in invasively ventilated patients admitted to the intensive care unit.
Primary aim: To establish reference values for exercise-induced elevations of cTn concentrations following walking, cycling and running exercise. Secondary aim: Assess the prevalence of (sub)clinical coronary artery disease in individuals with high…
To evaluate the safety, feasibility and efficacy of an 8-week remotely supervised home-based maintenance exercise training program following pulmonary rehabilitation in patients with COPD.
3. STUDY OBJECTIVES3.1. Primary ObjectivesThe primary objectives are:• To determine if CAEL-101 and treatment for PCD improves overall survival in Mayo stage IIIb AL amyloidosis patients who are treatment naïve compared to treatment for PCD alone•…
The primary objective of this study is to demonstrate the superiority of etripamil NS over placebo in reducing ventricular rate in patients with AF.
The general aim for this project would be to understand the neurodevelopmental differences with respect to implicit and explicit forms of threat regulation, by focusing on brain development, sex-steroid hormones and social sensitivity in adolescents…
1. Assess the effect of Ru-106 brachytherapy applicators on tumor dimensions. 2. Assess the value of DWI and PWI as an early predictor of therapy response after Ru-106 brachytherapy in UM.
Primary Objective:1. To evaluate the efficacy of sonelokimab at 2 different dose levels (120 mg, 240 mg) compared with placebo in the treatment of participants withactive moderate to severe hidradenitis suppurativa.Secondary Objectives:1. To…
To evaluate the effect of FICare in SFR on cognitive development at 5.5 years of age as measured by the WPPSI-IV in preterm infants hospitalised in a level-2 Neonatal Ward as compared to SNC in OBU To evaluate the effect of FICare in SFR on parental…
Primary Objective: To assess the safety of the single flap peritoneum vaginoplasty procedure by studying adverse events and complications during, directly after and within 90 days of the operation. Secondary Objectives: - To assess short- (12 weeks…