3434 results
The primary objective is to determine the quantity and quality of antibody and T-cell responses to SARS-CoV-2 in asymptomatic patients who tested positive for SARS-CoV-2 with RT-PCR prior to interventions. The secondary objectives are:- To determine…
The aim of this study is to establish how many employees at Reade have had an infection with SARS-CoV-2, tested with a novel assay for the detection of antibodies against SARS-CoV-2 developed by Sanquin. This study will focus on our own institute,…
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
Main objective:- Evaluate the anti-tumor activity per RECIST 1.1 in participants with metastatic or locally advanced/unresectable urothelial cancer treated with bintrafusp alfa. Secondary objectives: - Evaluate other measures of antitumor activity…
The current project aims to assess both the effectiveness and cost-effectiveness of an internet-based insomnia intervention (i-Sleep) in addition to usual care for depression, compared to usual care alone, in depressive patients with comorbid…
Assess the efficacy of BAY1817080 as compared with placebo in terms of change in 24-hour cough count from baseline to week 12. Further assess the efficacy, safety and tolerability profile of BAY1817080 in patients with RCC
The aim of this study is to validate the accuracy of SNNS for the detection of tumor-positive LNs using lymphoscintigraphy with radioactive tracer and NIR with ICG in patients with early EAC with regional LN involvement (clinically staged as T1N1).
Primary objectives:1. To determine the gene frequencies of HLA-A, B, C, DR and DQ in patients with autoimmune encephalitis and compare this to the general Dutch population. 2. To determine genetic risk factors for the development of autoimmune…
To evaluate the physiological effects, feasibility, tolerability and safety of CPAP via a face mask in patients with COVID-19 pneumonia requiring high inspired oxygen fractions during spontaneous breathing.
To gain insight into how people with CP of 40 years or older experience their citizenship and how these adults can be supported in their citizenship. How their citizenship has changed over time. To develop posters for rehabilitation practice to gain…
To be able to further investigate the benefit of these interfascial plane blocks we want to perform a randomized controlled trial. Since the effect on postoperative pain of PECS II was similar to PECS I + ESB, we only use the PECS II as an…
To study if a blended personalized periconception lifestyle care approach aimed at women with a high risk for pregnancy complications who are contemplating pregnancy or already pregnant (*12 weeks) can significantly reduce Lifestyle Risk Score.
Primary objective:To evaluate the safety and tolerability of a single dose of DCR-PHXC in patients with PH3Secondary objectives:To characterize the plasma PK of a single dose of DCR-PHXC in patients with PH3To assess the efficacy of a single dose of…
to determine the effect of dietary restriction and the ketogenic diet on the regression of hepatocellular adenoma after 6 months.
To determine the feasibility of additional flushing of the fallopian tubes with Lipiodol after tubal testing with methylene-blue during THL.
1) describe the urinary excretion kinetics of ZEN biomarkers; 2a) determine duration of urine sampling for ZEN biomonitoring studies; 2b) describe interindividual differences in formation of *-zearalenol (*-ZEL) and *-zearalenol (*-ZEL) from ZEN in…
Validation of rapid tests for SARS-CoV-2 in primary care emergency services
To determine the unique contribution of physical activity on PTSD treatment outcome within an intensive TFT programme. In addition, the study aims to investigate the underlying biological and psychological pathways of the effects of physical…
The objective of the stutdy is to 1) identify whether ECAs can persuade community-dwelling older adults to dietary behaviour change and decrease loneliness, 2) test these pathways to effects, and 3) understand use of an ECA.
The aim of the study is to assess whether early administration of the drug tocilizumab in SARS-CoV-2 infection (COVID19 - coronavirus) can prevent the risk of death and mechanical ventilation (assisted respiration by a ventilator).