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Pilot Study of Faecal Microbiota Transplantation in Multiple Sclerosis, a Phase-1 Study

Overall the safety to perform FMT has to be assessed before potential trial powered for efficacy can be performed. In this study we aim to treat 10 patients with different forms of MS to assess if FMT is safe to perform.Primary Objective: To assess…

Dupilumab in adults with severe chronic hand eczema with an inadequate response or intolerance to alitretinoin: a randomized, double-blind, placebo-controlled proof of concept efficacy study

Main study:To evaluate the efficacy of dupilumab in patients with inflammatory subtypes of severe chronic hand eczema with an inadequate response or intolerance to alitretinoin and in patients with concomitant positive patch test results.Substudy:…

SpHincterotomy for Acute Recurrent Pancreatitis

The hypothesis is that obstruction at the level of the minor papilla is one cause of RAP in pancreas divisum; miES will relieve the obstruction, thereby reducing the risk of a recurrent attack(s) of acute pancreatitis.

Transmission and colonisation of pertussis among Dutch high-school adolescents.

This pilot study is designed to evaluate the feasibility of field activities and if necessary adjust the methods for the full-scale study. Primary Objective: to evaluate the recruitment, retention and compliance rates for a prospective cohort study…

Functional Renal Hemodynamics in Patients with Renal Artery Stenosis 3

To study the clinical value of pressure and flow assessment for predicting treatment response to PTRA and validate the pressure gradient assessment by CFD in patients with available CT angiography.

Effects of IVF culture conditions on the embryonic genome, methylome and transcriptome: a study to evaluate the safety and quality of different culture systems

To study the effects of in vitro culture conditions, such as different culture media or oxygen tension, on omic layers (i.e. genome, epigenome and transcriptome) of preimplantation human embryos and to relate this to chromosoom instability (CIN).

A study of non-invasive diagnostic techniques in renal osteodystrophy: 18F-sodiumfluoride positron emission tomography and serum non-oxidized PTH compared to bone histomorphometry

To assess accuracy of 18F-sodiumfluoride (NaF) positron emission tomography (PET) and serum non-oxidized parathyroid hormone (PTH) as an accurate, reliable and easy applicable diagnostic tools for the assessment of bone turnover in chronic kidney…

A Multi-Center, Low Interventional Study with a Retrospective Component in Participants with Late Onset Pompe Disease

Primary Objective:The primary objective of this study is to establish the occurrence of neutralizing antibodies to SPK-GAA capsid in participants with LOPD on an enzyme replacement regimen. Secondary Objective:The secondary objectives of this study…

EFFECTS OF ANTIBODY REMOVAL BY IMMUNOADSORPTION ON THE IMMUNE PHENOTYPE IN PATIENTS WITH ANTIBODY MEDIATED DISEASES - A *TARGET-TO-B* STUDY

1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…

*Evaluating the effect of qualitative feedback on asthma control in adults with difficult to treat asthma by improving therapy adherence and inhalation technique*

The primary objective of this study is to improve asthma control in adults with difficult to treat asthma, by increasing therapy adherence and inhalation technique with qualitative feedback.

Immune response during and after reactive hemophagocytic lymphohistiocytosis (HLH)

We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH

The Promysed Land: Clinical use of additional cardiac imaging and biomarkers in diagnosis and evaluation of cardiac sarcoidosis

The aim of the study is in threefold: Firstly, examine whether conventional screening for cardiac involvement based on history and ECG followed by routine use of echocardiogram with strain and Holter monitoring will identify more patients with…

Effect of atrial pacing right ventricular function after openheart surgery

To investigate the effects of atrial pacing on right ventricular function and hemodynamics after open heart surgery.

Glioblastoma, Optimizing Logistics and Dose (GOLD).

To test whether extremely hypofractionated radiotherapy (6 x 6 Gy) is non-inferior to standard radiotherapy (30 x 2 Gy) in terms of overall survival in patients with newly diagnosed GBM. Secondary objectives are to establish and compare health…

Short-term combined acalabrutinib and venetoclax treatment of newly diagnosed patients with CLL at high risk of infection and/or early treatment, who do not fulfil IWCLL treatment criteria for treatment. A randomized study with extensive immune phenotyping.

This study has been transitioned to CTIS with ID 2024-511072-33-00 check the CTIS register for the current data. The aim is thereby to reduce the risk of serious infections and the need for regular CLL treatment.

A MULTICENTRE, SAD, AND MAD CLINICAL TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IV TREATMENT OF CALY-002 IN HEALTHY SUBJECTS AND SUBJECTS WITH COELIAC DISEASE AND EOSINOPHILIC OESOPHAGITIS

The objectives of Part B of the study are as follows: Primary: To assess the safety and tolerability of CALY-002 following multiple ascending doses administered IV in subjects with coeliac disease (CeD). Secondary: (1) To characterise the PK of CALY…

First-in-human Phase I dose escalation study assessing safety, tolerability and preliminary efficacy of immunomodulatory nanoparticles

The primary objectives of this trial are:- To determine the safety and tolerability of increasing doses of PRECIOUS-01 after intravenous (i.v.) administration in subjects with solid tumors;- To assess the effect of increasing doses of PRECIOUS-01 on…

A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to
Assess the Efficacy and Safety of Branebrutinib Treatment in Subjects with
Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or
Branebrutinib Treatment Followed by Open-label Abatacept Treatment in
Subjects with Active Rheumatoid Arthritis.

pSS: • To compare the efficacy of branebrutinib with PBO at Week 24 in the treatment of subjects with pSS• To compare the safety and tolerability of branebrutinib with PBO in subjects with pSSRA: • To compare the efficacy of branebrutinib with PBO…

Volatile organic compounds in exhaled breath for the detection of interstitial lung disease (VISION)

We hypothesize that exhaled breath analysis by eNose: is able to discriminate between patients with ILD, at risk for ILD (including post COVID-19 patients) and without ILD.

A Phase III, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of Single Agent Belantamab Mafodotin Compared to Pomalidomide plus Low-dose Dexamethasone (pom/dex) in Participants with Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 3)

This study has been transitioned to CTIS with ID 2023-508962-14-00 check the CTIS register for the current data. Primary objective:To compare the efficacy with belantamab mafodotin vs pomalidomide plus low dose dexamethasone (pom/dex) in…