341 results
The primary objectives1. To assess the safety and tolerability of intravenous tracer administration of ANXV-800CW in up to three doses (0.5 mg, 1.0 mg, 2.0 mg flat dose) in patients with RVO and/or DR2. To determine the feasibility of molecular…
The aim of the proposed RCT is to assess the effectiveness of the ReHab-TOAT approach in improving arm function and arm skill performance in daily life tasks in chronic stroke patients with either a severely or moderately affected arm-hand (i.e.…
Primary:To assess the effect of bilateral treatment with AAV5-hRKp.RPGR on functional vision as measured by vision-guided mobility assessment.Secondary:To assess changes after treatment administration in retinal function, functional vision, visual…
We aim to perform a proof-of-concept study to assess the effect of ATIs on the intestinal barrier and immune function in healthy volunteers. We hypothesise that the ATIs either directly affect the intestinal barrier function, or indirectly by…
This study aims to evaluate the PK profile and IIV of drug exposure in plasma in children (aged 6-17 years) receiving (elexacaftor-)tezacaftor-ivacaftor. Secondary objectives are to evaluate the relationship between covariates and PK parameters that…
We aim to obtain a transdiagnostic mechanistic understanding of the neural and psychophysiological correlates of avoidance behaviour
To investigate the potential role of systemic glucocorticoids in patient with axial spondylarthritis with high disease activity.
This study has been transitioned to CTIS with ID 2023-506359-68-00 check the CTIS register for the current data. This study investigates the safety and efficacy of the new drug anifrolumab in patients with Lupus Nephritis. The effect of anifrolumab…
Primary Objectives- To investigate the impact of dose reduction of 18F-FDG on image quality of PET-MRII in patients with melanoma. Secondary Objectives- To determine the maximum reduction of radiation dose for 18F-FDG PET-MRI as compared to…
Generation of (age-dependent) reference values **of leukocytes and their subtypes and of their products, as well as analysis of (age-dependent) IG / TR repertoire. In order to be able to distinguish the age-dependent effects from effects caused by…
Flow velocity measurements are more feasible proximal to a coronary stenosis than distal to a stenosis. The conservation of mass principle dictates that proximal flow velocity measurements can be used as a substitute for distal flow velocity…
Primary objective: To acquire motor maps of the BR and the MD muscles by using the pseudorandom walk method and assess their change after long-term motor learning. Secondary objectives: Compute muscle synergies from the motor maps and assess their…
The primary objective is to research whether the oral contraceptive pill in adolescents has a negative effect on emotion regulation in the form of fear acquisition and extinction. The secondary objective is to research whether a disruptive effect of…
The primary objective is to assess the effectiveness of exposure in vivo directly following implementation in adults with chronic musculoskeletal pain (CMSP). Secondary objectives are to assess procedural fidelity and its progression directly…
To characterize the immune response and gene expression profiles in blood of chronic HBV patients who present with a flare after treatment with antiviral therapy in order to be able to predict spontaneous resolution of flares in the future.
The primary objective of this study is to investigate the difference in brain activation in response to odour stimulation between patients and controls. The secondary objective is to investigate the relationship between smell ability and brain…
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
Primary objective: Is functional treatment (soft wrap and buddy taping) superior in recovering hand function (QuickDASH) compared to casting in patients with uncomplicated subcapital MCV fracture? Secondary objectives: patient satisfaction, grip…
Overall we aim for a more effective treatment of provoked vulvodynia with less relapse, taking into account the patients autonomy as an important key to long term cure. Primary outcome: Decrease of pain during (attempt to) penetration, measured by a…
the primary aim of this study is to evaluate the safety (adverse events and complaints) of submandibular duct ligation right after intraductal ethanol infusion into the submandibular salivary gland (Ethanol two-duct ligation [E-2DL] in order to…