18 results on atopic dermatitis
The research question of the underlying study is: What are the effects of GMA*s on children with atopic dermatitis/ food allergy and their parents as compared with individual visits on:- physical complaints- self management- quality of life
The purpose of this study is to investigate how safe the new compound RPT193 is when it is administered to healthy subjects. RPT193 has not been administered to humans before. It has been previously tested in the laboratory and on animals. RPT193…
To develop and validate transplant models of vitiligo and atopic dermatitis for drug testing.
The purpose of the study is to investigate how quickly and to what extent PF 04965842 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). A small part of the PF 04965842 to be…
Primary Objectives* To evaluate the safety and tolerability of repeated intradermal LPS challenges in healthy volunteers* To evaluate the local response in healthy volunteers after repeated intradermal LPS challenges performed 14 days apartSecondary…
Primary objective:To demonstrate superiority of Qutenza over low-dose capsaicin control in change from baseline to Week 12 in the 24-hr average pain intensity in subjects with PSNP.Secondary objective:• To demonstrate superiority of Qutenza over low…
To quantify and assess intra- and inter-subject variability in mast cell density among healthy male and female volunteers. Serum tryptase values will also be quantified.
Is CMPX-2030 effective in the transplant model of psoriasis
To compare the new IMF with the control IMF.
The primary objectives are to investigate attentional interference by somatosensory itch and pain stimuli in healthy subjects, both on a behavioural (SAT) level and a neurophysiological level (EEG alpha-desynchronization).Secondary objectives…
The purpose of the study is to investigate how safe MT-2990 is and how well MT-2990 is tolerated. It will also be investigated how quickly and to what extent MT-2990 is distributed in and eliminated from the body (this is called pharmacokinetics).…
Primary Objectives* To explore the pharmacodynamic effects of topically applied omiganan in patients with external genital warts* To explore clinical efficacy of omiganan compared to placebo in patients with external genital warts.Secondary…
The primary objective of this study is to evaluate the efficacy and safety of naltrexone in the treatment of itch in patients with burn wounds. The nature of the association(s) of the - reduction of the - intensity of itch with sleep and anxiety in…
To evaluate local complement activation/depositions after intradermal LPS challenge
Primary objectiveTo evaluate the mechanism of AITC-induced vasodilationSecondary objectivesTo evaluate the tolerability of local AITC administrationTo evaluate the effect of whole-body heat on generation of NOTo evaluate the effect of AITC and whole…
The goal of this study is to validate and interpret a new HRQOL instrument and to analyse commonly used outcome measurements (PGA, PtGA) in dermatology.
To evaluate the effects of IV administration of GSK3858279 in Ultraviolet B (UVB) burn inflammatory, cold pressor test and electrical pain test in the PainCart
By means of this in vivo study, we try to non-invasively get insights into the pharmacokinetics of PPD applied to the human skin. By studying penetration rate, penetration depth, allocation to different skin departments (stratum corneum, epidermis,…