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A mathematically correct PK-PD model will be developed that describes the depressant effect of propofol on breathing with and without a background of remifentanil.
Comparison of the gastrointestinal tolerance of two enteral nutrition formulae
The use of automated closed loop oxygen control in infants on infants with high flow nasal canulla (HFNC) support, will lead to higher amount of saturations within target range compared to manual control.
Fentanyl is highly lipophilic. Localizations with a thicker fatlayer absorp more fentanyl than localizations with a thinner fatlayer. When patients stick the patch in different localizations this can lead to different concentrations of fentanyl.…
There is a minimal interaction between edoxaban and tamoxifen and it can safely be used concomitantly
It is expected that dynamic leg and arm training and functional training with arm support can retard the progression of the disease at the level of muscle endurance and/or the functional abilities of the lower and/or upper extremity in boys who are…
increased gastric distention will induce greater activation in satiety related areas
Objective: The overall aim of this project is to asses the prognostic value of the characteristics of an echocardiographic surrogate pressure-volume loop on mortality and morbidity due to PAH.
1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…
Our hypothesis is that contratile segment impedance is a marker for EoE-disease activity (histological remission or active disease)
To demonstrate proof of principle for the elimination of malaria from Rusinga Island using the nation-wide adopted strategy of LLINs and case management augmented with mass trapping of mosquito vectors.
To quantify the amount of local anaesthetic in blood and tissue fluid in the Bellovac ABT system and in the blood circulation of the patient. The primary objective is to quantify the cumulative ropivacaine level when the blood should be retransfused…
Objective: To assess the diuretic effect of three standard glasses of beer, red wine and spirits in euhydrated elderly men.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
To determine the influence of oral medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel and their respective metabolites in cancer patients.
We hypothesize that TIPS placement has an significant effect on drug metabolism and bile acid metabolism.
Pulse oximetry is a non-invasive method allowing monitoring of the oxygen saturation of a patient. For many years now, it has been used in secondary care with great success. Recently, it is noticed that pulse oximetry is used more often in the…
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