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Hypersalivation or sialorrhea is one of the most frequently occuring side effects of clozapine use with an incidence ranging from 30 to 90%. In most cases it occurs at the start of clozapine treatment, mostly at night and persists during further…
Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
The goal of the study is to: 1. Improve daily functioning in patients with schizophrenia; 2. To improve behavioral observation in psychiatric nurses; 3. To implement CAT in the usual treatment of patients with severe mental illness.
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
We hypothesize that in this short term study the testproducts with added fibre will increase satiety, slower gastric emptying, will give a later blood glucose peak and that it will decrease energy intake when compared to the controlproduct.
Objective of this study is to assess the sensitivity of performance in a number of widely used tests for measuring driver impairment to the dose-effects of alcohol.
Development and validation of a clinical Proof-of-Concept study paradigm for determing the clinical utility of respiratory stimulants over the potential therapeutic dose range in the face of opioid respiratory depression and presences of hypercapnia…
The present study will investigate: 1. Whether drug-related cues activate the same neural networks as does the administration of the drug itself; 2. The implicit and explicit associations of alcohol and cannabis users; 3. The effect of acute doses…
1. A meal consisting of harder-textured foods leads to lower energy intake at a lunchtime meal compared to a meal with softer-textured foods; 2. The decreased energy intake of the meal composed of harder-textured foods will not be compensated at the…
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
Tamoxifen pharmacokinetics may be influenced by circadian rhythm. Endoxifen exposure may differ between morning administration of tamoxifen and administration in the evening. Amendment (1-apr-2013): Tamoxifen pharmacokinetics may be influenced by…
A follow-up clinic for intensive care units (ICU) survivors reduces the incidence of post traumatic stress disorder (PTSD) after 1 year of follow-up.
Tinnitus (Aurium) is a symptom characterized by the perception of sound or noise in the absence of any objective external physical source. This disorder affects millions of people worldwide; its precise pathophysiologic mechanism is unknown. It has…
1. Evaluation of pulmonary deposition of inhaled Tobramycin with 99mTc-DTPA tracer is feasible using SPECT-CT scans; 2a. Pulmonary deposition of Tobramycin improves with concomitant inhalation of carbon dioxide enriched ambient air; 2b. Pulmonary…
By introducing of PK-guided individualized dosing of pazopanib we hypothesize that the interpatient variability can be reduced by 50%.
To demonstrate proof of principle for the elimination of malaria from Rusinga Island using the nation-wide adopted strategy of LLINs and case management augmented with mass trapping of mosquito vectors.
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…
Objective: The overall aim of this project is to investigate acute effects of moderate- and high-intensity exercise in heart failure patients and their age- and sex-matched controls on brachial artery shear patterns.
The main objective is to investigate whether high frequency low dosage IVIg treatment is more effective than low frequency high dosage as maintenance treatment for CIDP. The secondary objective is to investigate whether high frequency low dosage of…