Zoeken naar een onderzoek

To determine the requirement of cysteine in preterm infants with different gestational ages and postnatal age.

1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…

A double-blind, randomized, double dummy, cross over, study
to assess the difference in efficacy between nebulisation of rhDNase in the morning versus nebulisation before going to sleep.

Inhalation of rhDNase before sleep increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase in the morning.

Stop worrying.

A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.

The effect of Marinol (tetra-9-hydrocannabinol) on the frequency of TLESRs.

Cannabinoid receptor (CB1) agonists, like marinol, lower the rate of TLESRs and can be useful in the treatment of gastroesophageal reflux disease (GERD).

Rotation of antihypertensive drugs in ethnic groups.

Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.

Cristalloid vs. colloid in patients with severe sepsis and septic shock.

To demonstrate wether there is difference in tissue oxygen tension and extravascular lung water while patients are being resuscitated with cristalloids or colloids combined with cristalloids.

A Double-Blind, Double-Dummy, Randomized, Placebo-Controlled, 3-Period, Crossover Study to Investigate the Effects of Ethanol and L-000830982 on Essential Tremor.

1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…

Tolerance and safety study of a new paediatric peptide feed.

N/A

The effect of loperamide in childhood idiopathic faecal incontinence: the compensation reflex of the anorectal complex and clinical outcome.

1. We hypothesize that children with solitary encopresis have a disturbed compensation reflex, eventually combined with aberrant huge rectal contractions; 2. We hypothesize that in children with solitary encopresis loperamide rectally given, will…

Double-blind randomised placebo-controlled cross-over study to investigate the safety and effectiveness of intrathecal glycine on pain and dystonia in Complex Regional Pain Syndrome type 1.

A large proportion of chronic patients with complex regional pain syndrome type 1 suffer from both neuropathic pain and dystonia. Findings from neurophysiological and intrathecal baclofen studies highlight an impaired inhibitory neurotransmission.…

SDD-SOD-trial.

Can mortality in ICU-patients be reduced by using SDD or SOD as infection prevention measure, without increasing the development of antibiotic resistance.

Ibopamine eyedrops in the treatment of hypotony after vitreoretinal surgery in retinal detachment or uveitis.

Administration of Ibopamine hydrochloride eye drops restores intraocular pressure in patients with hypotony following vitreoretinal surgery or uveitis.

Lycopene and Vitamin E in men with minimal prostate cancer and rising PSA after radical prostatectomy. A double blind randomised placebo controlled cross-over study.

A combination of Lycopene and Vitamin E decreases PSA progression.

A double-blind, randomized, double dummy, cross over, study
to assess the difference in efficacy between nebulisation of rhDNase before airway clearande therapy (ACT)versus nebulisation after ACT.

Inhalation of rhDNase after airway clearande therapy (ACT) increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase before ACT.

Protection against chemotherapy induced damage in the digestive tract in childhood cancer patients.

1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.

The effect of intraileal infusion of fat emulsions, differing in degree of saturation, on satiety and food intake after a liquid meal replacement.

Long-chain triglyceride (LCT) emulsions with di-unsaturated fatty acids will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with mono-unsaturated or saturated fatty acids.

Effects of aspirin on markers of inflammation and coagulation in subclinical atherosclerosis in type 2 diabetic subjects.

An early intervention with low-dose aspirin in asymptomatic diabetic subjects attenuates progression of atherosclerosis, by decreasing inflammation and coagulation.

A preference trial with naratriptan 2,5 mg and paracetamol 1000 mg in migraine patients in the general practice.

Patients prefer naratriptan over paracetamol 1000 mg for the acute treatment of migraine attacks.

Fatty Acid Induced Oxidative Stress: it's role in preventing hypoglycemia.

Elevated levels of Free Fatty Acids during fasting induce oxidative stress and cause insulin resistance to maintain euglycemia.

MEN-Study: A randomized cross-over study on the effects of the skin patch and the vaginal ring versus a levonorgestrel containing oral contraceptive on the anticoagulations pathways.

The effect on APC-resistance of the skin patch and the vaginal ring contraceptives, containing third generation gestagens, is significantly increased in comparison with oral contraceptives, containing second generation gestagens.