155 resultaten
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.
We hypothesised that this strategy could lead to a considerable and relevant change of prescribing behaviour in the desired direction.
1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…
Different processing of milk products will have impact on metabolic availability of amino acid
Overall: when kidney function deteriorates, regulation of the potassium balance in response to potassium loading switches from renal to non-renal mechanisms. 1. Serum potassium in CKD is mainly influenced by alterations in the internal potassium…
A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.
we hypothesize that thermal comfort and sensation will stay within similar ranges in both conditions (based on a previous study);
Inhalation of rhDNase before sleep increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase in the morning.
Prolonged ingestion of chocolate milk during a training program improves the sports performance parameters in badminton athletes more than control.
Depressive symptom severity is reduced more by active DBS than sham DBS.
Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
To demonstrate wether there is difference in tissue oxygen tension and extravascular lung water while patients are being resuscitated with cristalloids or colloids combined with cristalloids.
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
Cannabinoid receptor (CB1) agonists, like marinol, lower the rate of TLESRs and can be useful in the treatment of gastroesophageal reflux disease (GERD).
This is an exploratory pilot study without specific hypotheses.
1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.
Long-chain triglyceride (LCT) emulsions with di-unsaturated fatty acids will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with mono-unsaturated or saturated fatty acids.
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.