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Het vinden van een biologische verklaring voor het feit dat bij een deel van de migrainepatiënten sumatriptan niet effectief is.
Vergelijking van de bloeddruk verlagende effecten van thiazide diuretica met calciumantagonisten in CNI-geïnduceerde hypertensie.
Fundamenteel onderzoek, gericht op het vergroten van kennis over empathische processen bij personen met psychopathie. Er wordt geëvalueerd of de affectieve empathische functies tijdelijk (minuten) kan worden beïnvloed.
Onderzoeken of voorbehandelen met metformine een gunstig effect heeft op flow mediated dilation na 20 minuten ischemie en 20 minuten reperfusie. Indien metformine voorbehandeling inderdaad endotheliale ischemie-reperfusieschade limiteert, zullen wij…
Het beoogd resultaat is het ontdekken van een effectievere, simpele, goedkope en gebruiksvriendelijkere behandeling voor houdingsafhankelijk OSAS dan de huidige therapieën. Houdingstherapieën worden al als reguliere behandeling gegeven in het…
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Deep brain stimulation of the nucleus accumbens decreases drug use and craving in treatment refractory heroin and/or cocaine dependence.
We hypothesize that implementation of a workers's health surveillance and consecutive interventions will lead to prevention of injury and disability, health improvement, and eventually sustained employment.
Development and validation of a clinical Proof-of-Concept study paradigm for determing the clinical utility of respiratory stimulants over the potential therapeutic dose range in the face of opioid respiratory depression and presences of hypercapnia…
1. A meal consisting of harder-textured foods leads to lower energy intake at a lunchtime meal compared to a meal with softer-textured foods; 2. The decreased energy intake of the meal composed of harder-textured foods will not be compensated at the…
The aim is to investigate the effects, costs, and feasibility of an evidence-based professional-directed implementation strategy to implement the Dutch peri-operative guidelines, i.e. to achieve a higher adherence to these guidelines. It is…
A follow-up clinic for intensive care units (ICU) survivors reduces the incidence of post traumatic stress disorder (PTSD) after 1 year of follow-up.
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
We hypothesise that fasting-induced insulin resistance will result in decreased glucose uptake and activity of brown adipose tissue (BAT). In addition, prolonged fasting will lead to reduced mitochondrial uncoupling in skeletal muscle, which is…
To investigate if flavour flavour learning is an effective mechanism to increase children's vegetable intake.
A high-glucose load can lead to inflammation and it is thought that recurring hyperglycemia may lead to insulin resistance. Our aim is to prevent glucose-induced inflammation and decreased insulin sensitivity with broccoli seedlings which are…
The protein status of an individual effects food preferences and intake. If the protein status is low, products high in protein will elicit greater reward.
Part 1: To determine the respiratory response of low and high doses of GAL-021 in conjunction with a low dose of opioids and hypercapnia in healthy subjects. Part 2: To determine the respiratory response of low and high doses of GAL-021 in…