131 resultaten
Het doel van het onderzoek is te onderzoeken hoe snel en in hoeverre flurbiprofen in het lichaam wordt opgenomen en uitgescheiden (dit wordt farmacokinetiek genoemd), wanneer het wordt toegediend in de vorm van FTS. Ook zal de farmacokinetiek van…
(1) Het bepalen van het effect van deafferentiatie op pijnverwerking in het brein m.b.v. taak fMRI(2) Het bepalen van het effect van deafferentiatie op reactietijd (sedatie) m.b.v. taak fMRI(3) Het bepalen van het effect van deafferentiatie op…
Het doel van deze studie is voornamelijk om de werkzaamheid van geïnhaleerd mannitol te vergelijken met een placebo in proefpersonen met Cystic Fibrose tussen 6 en 17 jaar.Wij veronderstellen dat geïnhaleerd mannitol de algemene gezondheid en de…
Het bepalen van de drempelwaarde voor detectie van onderbrekingen in spraak-achtige stimuli in CI gebruikers (en NH controle proefpersonen) en bestuderen van de verschillen tussen directe stimulatie (door middel van research-interface) en stimulatie…
In this randomised controlled study, the effects of art therapy is examined on psychological functioning of patients with a personality disorder. It is expected that art therapy results in less personality pathology, more acceptance, and less…
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome requiring long-term TPN.
Roux-en-Y Bariatric (RYGB) surgery is a successful approach to morbid obesity. In this procedure, the stomach is reduced to a small 'gastric pouch' . The duodenum is bypassed by connecting the jejunum this gastric pouch. The duodenum is…
Sumatriptan can block the increase in dermal blood flow (DBF) caused by application of capsaicin or electrical stimulation.
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
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Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
A 4 hour intervention period with the new disease-specific tube feed will result in a better plasma glucose profile as compared to an isocaloric standard tube feed.
To investigate whether either chlorhexidine-alcohol or iodine-alcohol based skin antiseptics is more protective against surgical site infections.
Influence of oxynorm melt tablet versus paracetamol melt tablet on pain relief in healthy volunteers
The main aim of the study was to quantify the temporal antinociceptive profile of administration of oxynorm orodispersible tablets versus orodispersible paracetamol tablets. We hypothesize that oxycodone produces greater analgesia than the active…
There are many orthoses available to treat the symptoms caused by thumb carpometacarpal osteoarthritis. It is however not known which type reduces pain the most, which orthosis is preferred by patients and which factors influence compliance with…
Inhalation of the recommended dose of tobramycin with the I-neb nebuliser is equivalent and as safe compared to the standard PariLCPlus nebuliser in children with CF.
We assume equal improvement of physical function in both groups and reduced costs with conservative treatment.
We expect that there will be a difference in energy intake after 2 weeks of supplementation of a bar with 10g added fibre out of chirory root pulp (CRP) compared to 2 weeks of supplementation of a control bar. We hypothesize that the energy intake…
Inhalation of a single regular dose steroid (200ugr Qvar autohaler) with a stretched upper airway (achieved by leaning forward and flexing the head backwards) will protect more against exercise induced asthma compared to inhalation of a single…