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An explorative study on physiological and neurophysiological determinants of fatigue in cancer survivors.

1. What are characteristic (neuro)physiological factors of fatigue in disease-free cancer patients? 2. To which degree can these factors be influenced by Cognitive Behavior Therapy?

EQMI-trial: Endoscopische Quad-Modal Imaging en moleculaire eindpunten ter opsporing van vroege neoplasie in Barrett oesophagus.

1. In Barrett Esophagus (BE), probe-based laser endomicroscopy (pCLE) provides better correlation with the histological diagnosis compared to detailed inspection with Narrow Band Imaging (NBI), reducing the high rate of false-positive findings with…

Gelijktijdige brachytherapy en biodegradable stentplaating bij inoperbale slokdarmkanker.

Het is veilig en haalbaar om in 1-2 gastroscopieen zowel een BDstent te plaatsen als brachytherapie toe te dienen.

A comparison between two bracing methods in idiopatic scoliosis: the Boston and a new developped brace.

The new developed brace gives better correction by higher body brace interface pressures than the gold standard Boston brace.

NAVA study.

NAVA (neurally adjusted ventilatory assist) is a newform of artificial respiration, based on the electrical activity of the diafragma. We want to investigate wether there are fysiological differences between the conventional mode and NAVA.

A surgical safety checklist to reduce complications.

By using a surgical safety checklist, the incidence of postoperative complications will decrease.

A Phase II study combining short course radiotherapy, chemotherapy and resection of the rectum and metastases in primary metastasized rectal cancer.

1. Curative treatment of primary metastasized rectal cancer includes resection of primary tumor and metastases; 2. Primary tumors in case of metastasized disease are often locally advanced and need downsizing before resection; 3. Systemic treatment…

Flat colorectal cancer precursor lesions: epidemiological aspects and molecular analysis.

1. Flat adenomas are common findings in patients at average- or at high-risk for CRC; 2. Flat adenomas are characterized by a different molecular profile as compared to polypoid lesions; these molecular features are associated with an increased risk…

Astma ontstaan op volwassen leeftijd: de eerste twee jaar.

The aims of the present study are: 1. To give a comprehensive description of 200 adults (> 18 yr) with recently diagnosed adult-onset asthma (< 1 yr); 2. To define clinical, lung function or inflammatory or mixed phenotypes of adult…

Research in Acute appenDIcitis and mAgnetic resonaNCE imaging.

To determine the sensitivity and specificity and positive and negetive predictive value of MRI in a consecutive series of pediatric patients suspected for acute appendicitis.

Adult Onset Asthma: the first 5 years.

Phenotyping of patients with adult onset asthma by linking clinical, functional and molecular markers will: 1. Reveal distinct risk factors of severity and poor quality of life; 2. Provide evidence that recent onset asthma in adulthood is relatively…