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We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
A TCS is comparable to TCC and an effective treatment in neuropathic forefoot ulcer,
to improve the medical care on long term follow up
Gut dysbiosis drives disease processes driving morbidity and mortality in acute pancreatitis, such as infected pancreatic necrosis, and (persistent) multiple organ failure. A decrease in commensal members of the bacterial microbiome allows for…
Prevalence of PNH in selection of patients with DVT. Patients younger than 30 years of age. patients with DVT on unusual places.
Part 1: Primary: Patients who are more susceptible to nocebo effects at baseline will have greater clinical pain progression from baseline to one-year follow-up. Secondary 1: Patients who are more resilient to extinction will have greater clinical…
Pelvic organ prolapse (POP) is a common condition in middle aged and elderly women. Approximately 10% of women will have surgery for POP and/or urinary incontinence during their lifetime [3, 4]. POP can occur in the anterior, posterior or apical…
An intervention in hand hygiëne should increase hand hygiëne compliance. An intervention will be implemented at two different moments to see which is more succesful.
It is expected that the dynamic version of the Wisconsin Card Sorting Test (dWCST) is a valid measure of cognitive learning potential in terms of psychometric properties and construct validity. In terms of feasibility it is anticipated that the…
Preterm infants are at risk for neurodevelopmental impairment, but also for obesity and risk factors of cardiometabolic diseases. Nutrition in the early neonatal phase and altered early growth might be predisposing these risks. Early body…
Preoperative, intraoperative and postoperative recorded music interventions have been proven effective in reduction of pain and anxiety. Also, recent reviews and meta-analyses provide significant evidence for lower postoperative stress response,…
Implementation of Module CH leads to better tailored care, improved functioning of the user and more efficient use of absorbent incontinence aids.
We expect the SPOT-25 to correlate with all three measurement instruments. We expect correlation between the change score in the “hearing function” domain of the translated SPOT-25 and the Glasgow Benefit Inventory to be higher than correlation…
VTE risk prediction might be improved by using the modified risk scores.
It is increasingly recognized that the immune system is a major player in this obesity related disease and the switch from benign to malign (insulin resistance and DM2) obesity is associated with changes in the immune system . In this regard, animal…
This study aims to increase the implementation of smoking cessation group trainings with financial incentives among Dutch companies by developing an implementation strategy that will be tested, evaluated and adapted multiple times. We hypothesize…
The primary objective is to prospectively identify cardiac damage in childhood cancer patients, during and shortly after treatment with anthracyclines.
The aim of this study is to describe the last phase of life of people with young-onset dementia. The research questions for this prospective observational study are: 1. What is the practice of end of life care in people with young-onset dementia…
We expect a high long-term effectiveness, patient satisfaction and cosmetic outcome of therapeutic ultrasound-guided vacuum biopsy of breast fibroadenomas.
In recent years a relationship between low skeletal muscle mass, as measured using routine diagnostic CT scans, and chemotherapy related toxicity has been suggested in a variety of tumour types including head and neck squamous cell carcinoma (HNSCC…