132 resultaten
1. Muscle ultrasound is capable to detect dermatomyositis and polymyositis in suspected patients; 2. Muscle ultrasound is capable to detect improvement of structural muscle changes induced by treatment; 3. Muscle ultrasound is capable to detect…
The primary goal of this study is to determine whether it is possible to discontinue treatment with TNF blocking therapy in patients suffering from Rheumatoid Arthritis when the patient has had stable low disease activity.
Increasing kidney function by kidney transplantation might improve the circadian rhythms of melatonin concentration, sleep and 24-hour blood pressure profile.
1. Participation in an early home-based education programme compared to care as usual will significantly increase knowledge on kidney disease and treatment options, communication on renal replacement options and promote a positive attitude towards…
Nebulizing amoxicillin clavulanic acid is more effective for reaching amoxicillin levels in sputum > MIC90 than amoxicillin clavulanic acid given by oral or intravenous administration.
We aim to use Epstein-Barr Virus (EBV) within nasopharyngeal carcinoma (NPC) tumour cells as therapeutic target. In these cells EBV “hides” in a latent state due to methylation of the viral promoters, expressing only few non-immunogenic viral…
Remote ischemic preconditioning (RIPC) has been shown to attenuate myocardial damage in cardiac surgery. We hypthesize that RIPC induced cardioprotection is associated with an increased amount of mitochondrial hexokinase.
1. The first hypothesis is that treatment of panic disorders with or without agoraphobia with EMDR as well as with CBT will lead to symptom reduction. This symptom reduction is expected to be larger in the EMDR treatment group than in the CBT…
Develop a screening tool to identify children at risk of posttraumatic stress disorder after an accident.
We hypothesize that higher distress levels will be associated with higher perceived need for and actual use of health care services, and with higher individual health care and work-loss related costs.
We aim to validate Massive Parallel Sequencing in Primary Ciliary Dyskinesia (PCD) and identify novel disease causing mutations in the Dutch PCD population.
1. Breathprints, generated by an electronic nose, variate during mechanical ventilation; 2. Breathprints correlate with biological markers for oxidative stress and lung injury during mechanical ventilation.
EN - Unrelieved chronic pain represents a major problem for individual patients and is also a socio-economic burden for health services and the community at large. Although the etiology of musculoskeletal chronic pain following trauma is not well…
Moderate weight loss increases sensitivity to β2-AR-stimulated lipolysis in isolated adipocytes from subcutaneous adipose tissue biopsies.
Co-infection with either HIV or malaria may have a major impact on the immune response during bacterial sepsis. Current knowledge on the pathogenesis of sepsis indicates an unbalanced response to infection characterized by both excessive pro-…
The aim of the meta-analysis is to investigate the early predictive value of migration measured by RSA 2 years post-operatively for revision for aseptic loosening of the acetabular component in THA and to compose migration thresholds for safe and…
In this randomized crossover pharmacokinetic study we will investigate the effects of cytochrome P450 enzyme induction (including CYP3A4, CYP2C and CYP2D6) by rifampicin on the metabolism and plasma pharmacokinetics of tamoxifen and its metabolites…
What are the causes of interval colorectal cancers? Are they the result of technology related or biology related factors? 1. Interval colorectal cancers (CRCs) are more common than expected; 2. Interval CRCs are characterized by a different…
Does addition of lenalidomide to chlorambucil and rituximab result in better response rates with acceptable toxicity.