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Objectives Primary: To examine the effects of regular glucose lowering treatment on inflammatory markers in type 2 Diabetes Mellitus Secondary: To identify markers/fingerprints that predict the response of a patient to glucose lowering therapy in…
we would like to investigate whether multiple fecal transplantations using either allogenic (lean preferably vegetarian/vegan donor) or autologous (own) donors have a beneficial effect on non alcoholic steatohepatitis (NASH) using biopsy and MRI…
In this observation study we hypothise an incidence of UTIs of 30% in the first year after starting CIC. Moreover we hypothise a marked reduction in quality of life and an increase in health care expensis in patients with UTI.
The maternal diet is highly responsible for the composition of breast milk which will result in at least differences between cultures and geographical separated populations. The maternal diet and breastmilk composition will show off in the…
The primary objectives of this project are: - Identify neural correlates and behavioural measures that underlie cognitive processes that perpetuate CFS symptoms - Identify neural mechanisms of change that mediate successful CBT.
This study will explore the feasibility of post-transplant panobinostat combined with decitabine after reduced intensity conditioning (RIC) alloHSCT in patients with (very) poor-risk AMLor RAEB with IPSS >= 1.5 (AML/RAEB). While recent…
The introduction of ultrasound will give reduction of at least 25% in radiation burden on healthcare professionals in the pain clinic
The hypothesis is that immunization against VEGF will circumvent the specific drawbacks of the current anti-VEGF treatment modalities. The primary objectives of this study are to investigate the safety and tolerability of hVEGF26-104/RFASE and to…
18F-FDHT PET/CT is expected to be a predictor of response in patients with metastasized castration-resistant prostate cancer to be treated with enzalutamide
The aim of the study is: (1) observational, i.e., to assess and describe the responses of patients and volunteers to a variety of different stimulation paradigms; (2) diagnostic, i.e., to assess whether specific tests are possibly diagnostic for…
The percentage of successful PIV insertions at the first attempt in newborns will increase with the Veinviewer® and/or Astodia®, two vascular imaging devices
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The objective of this study is to assess the technical feasibility of the EsoFLIP dilation balloon in the treatment of achalasia.
We hypothesize that by stimulation gesture-plus-word combinations the expressive language development will improve.
Laparoscopic Fluorescent near-infrared imaging using ICG can accurately detect liver metastases from uveal melanoma intra operatively.
We expect an improvement in psychological flexibility and a decrease in pain interference in daily life or in fatigue. Furthermore, we expect a decrease in depression and anxiety symptoms.
Think different: effectiveness of an online training for children with obsessive-compulsive disorder
The aim of the present study is to improve treatment for children with OCD by adding an online Cognitive Bias Modification-Interpretation (CBM-I) training as a pre-treatment to cognitive behavioural therapy (CBT). CBM-I is compared with a waitlist…
People with aphasia have problems with communicating. Because communication is very important in the society, these group suffers from a smaller social network, diminished social participation and as a result of this, loneliness, a loss of autonomy…
1. Different neuropathological mechanisms in Parkinson's disease and atypical Parkinsonism concerning the risk of falling; 2. Research concerning the diagnostic accuracy and sensitivity of VEMP and SVV.
Sunitinib, when given in a high-dose, intermittent schedule, may exhibit improved efficacy with an acceptable toxicity profile.