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Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) for colorectal cancer screening.

Investigate whether DWIBS is effective for colorectal cancer screening.

Acropolis study

Comparison of the gastrointestinal tolerance of two enteral nutrition formulae

The evaluation of renal damage caused by iodinated contrast media used to enhance images in computer tomography scanning by assessing multiple serum and urinary parameters.

1. Pre- and post-hydration using a sodium bicarbonate infusion scheme is an effective method to prevent CIN from occurring. 2. The current protocol is efficient in identifying high risk patients. 3. Microalbuminuria and microglobulinuria can…

Safety and Efficacy clinical trial of the PTMA System to reduce mitral valve regurgitation in heart failure.

Reduction of the severity of functional mitral regurgitation using a percutaneously delivered implanted device.

A diagnostic studie:
Mannitol challenge test in patients with mild to moderate COPD

To investigate the diagnostic value of the mannitol challenge test compared to the eosinophilic inflammation in the airways.

A multi-centre randomized trial comparing Radiofrequency Ablation with Radical Endoscopic Resection for treatment of Barrett's Esophagus with High-grade Dysplasia or Early Cancer.

Open Access Echocardiography in the Netherlands

Open Access Echocardiography will reduce costs of cardiac care and will improve diagnostics and therapy in primary care

RCT of Cognitive therapy and Schematherapy for comorbid anxiety- and cluster C personality disorders.

The objective of this project is to gain knowledge about the how and when of cognitive behavioral treatment (CBT) of Axis I anxiety disorders when there is co-morbidity of an Axis II cluster C personality disorder. It tries to answer the question…

The diagnostic accuracy of exhaled breath fingerprinting by eNose in diagnosing asthma and atopy.

We postulate that exhaled breath sampling by an electronic nose can distinguish and adequately identify smell-prints from: 1. Atopic patients without airway obstruction 2. Non-atopic patients without airway obstruction 3. Atopic patients with…

Effects of rosuvastatin on the pharmacokinetics of imatinib.

A possibly competitive inhibition between imatinib and rosuvastatin as substrates for the same solute carriers (i.e. OATP 1A2 and ABCG2) may result in drug-drug interactions and altered pharmacokinetics of imatinib.

NGAL an early biomarker for acute kidney injury

NGAL is an early predictive biomarker for acute kidney injury in a heterogeneous adult ICU population.

Effect of Celecoxib on reponse, progression-free and overall survival, when added to standaard first line chemotherapy in advanced ovarian cancer.

Primairy Objectives: - To evaluate the antitumoral efficacy of celecoxib in combination with docetaxel/carboplatin in terms of: a) response (cCR, cPR, NC, PD) b) progression-free survival Secundairy Objectives: -To evaluate the safety and…

The value of diffusion-weighted MR imaging and biomarkers in cerebrospinal fluid in acute spinal cord injury as predictors of outcome.

Prospective study determing whether MRI-Diffusion Weighted Imaging (DWI) and biomarkers in CSF have prognostic capabilities in patients with Spinal Cord Injury (SCI).

Connectivity and networks in epilepsy patients with cranial tumors

- Epilepsy patients with brain tumours show altered functional connectivity and networks in the brain compared to healthy controls - Connectivity and networks change over time as a function of treatment

Sentinel Node And Recurrent Breast cancer

Due to surgery and radiotherapy lymph drainage pathways in recurrent breast cancer could be altered. These aberrant drainage pathways could be detected with lymphatic mapping and sentinel node biopsy leading to a more thorough staging and possible…

Efficacy and safety of home treatment versus in hospital treatment with LMWH in patients with non-massive pulmonary embolism

Outpatient LMHW treatment in patients with objectively proven non-massive pulmonary embolism is efficacious and safe.

Evaluation of the clinical impact of ventricular dyssynchrony in patients with corrected tetralogy of fallot

Improvement of the RV function by pulmonary valve replacement will result in improvement of RV dyssynchrony in corrected tetralogy of Fallot patients

Prevalence, severity and origin of lymphedema among women five years after treatment for breast cancer.

A randomized phase III study of adjuvant chemotherapy with or without low-molecular weight heparin in completely resected non-small-cell lung cancer patients with high-risk for recurrence: NVALT 8B

Gives the addition of nadroparine during adjuvant chemotherapy in NSCLC a prolongation of the disease free survival?

Prospective collection of data of patients with a proximal femoral fracture: an observational study.

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