456 resultaten
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
In this explorative study we will examine the impact of daily ischemic preconditioning on brachial artery endothelial function (measured as FMD%, before and after IRI) during 7 days in the non-shunt arm and lower limb in patients with end-stage…
Prevalence of PNH in selection of patients with DVT. Patients younger than 30 years of age. patients with DVT on unusual places.
Different studies have shown that a hunter-gatherer type diet is effective in improving glucose regulation and lipid profile. I want to investigate if the hypothese that this type of diet also reduces the number of physical and psychological…
Pelvic organ prolapse (POP) is a common condition in middle aged and elderly women. Approximately 10% of women will have surgery for POP and/or urinary incontinence during their lifetime [3, 4]. POP can occur in the anterior, posterior or apical…
An intervention in hand hygiëne should increase hand hygiëne compliance. An intervention will be implemented at two different moments to see which is more succesful.
RRT activation rate within a hospital or wards within a hospital are likely to be associated with specific factors regarding possible delay in escalation of care for deteriorating patients. This research is focussed on elucidating factors which may…
Based on the results obtained in our previous study (Ruiter, Kolk, Rietveld, Dijkstra & Lotgering, 2011), we hypothesise that: - The experimental changes to the scenarios and new quantitative scoring procedure of the Amsterdam-Nijmegen…
- Hypothesis#1 efficacy We hypothesize that a quick onset, and a predictable dose-response, good adjustability of analgesia can be achieved with inhaled ketamine. Hypothesis#2 safety Inhalation of nebulized ketamine might lead to a fast onset of…
Perfusion Angiography, in relation with known parameters, describes the ultimate prognostic model in revascularized Critical Limb Ischemia patients.
Rationale: Patients with a psychotic disorder are impaired on many aspects of social functioning and self-management. Consequently, social and emotional isolation is highly prevalent. Furthermore, clinic based (social) skills training tends not to…
Preterm infants are at risk for neurodevelopmental impairment, but also for obesity and risk factors of cardiometabolic diseases. Nutrition in the early neonatal phase and altered early growth might be predisposing these risks. Early body…
Our hypothesis is that high-dose, pulsatile sorafenib may exhibit improved efficacy with an acceptable toxicity profile compared to standard continuous dosing. AUC escalation cohorts are used instead of the conventional dose escalation cohorts,…
Exploration of the effects of AAT in adults with an Autism Spectrum Disorder (because this study has an explorative character, there is no hypothesis formulated)
Does MS grey matter pathology progress faster in regions with more damage in connected white matter?
Our hypothesis is that MS grey matter pathology, and thereby disease burden and clinical outcome, can be better predicted by looking at damage in the connected white matter in early RRMS patients
MIA is a good alternative for the CA, with comparable diagnostic performance. It will lead to an increase in clinical autopsy rates, which have significantly decreased over the last decades in both academic and non-academic medical centers.
Treatment of a subcapital metacarpal fifth fracture with a compression bandage gives the same functional outcome a treatment with paris plaster
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Patients subject to MET review have a high in-hospital mortality (20%). Thus, understanding the outcome of patients within the first 24hr of MET review is important in developing quality improvement and interventional studies to reduce this…
This study will be an open observational study with the objective to test the feasibility of the mDLS. The variability of the methodology over time will be assessed. Blood flow and coagulation status assessed by mDLS and LSCI will be compared with…