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We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
to improve the medical care on long term follow up
Gut dysbiosis drives disease processes driving morbidity and mortality in acute pancreatitis, such as infected pancreatic necrosis, and (persistent) multiple organ failure. A decrease in commensal members of the bacterial microbiome allows for…
Prevalence of PNH in selection of patients with DVT. Patients younger than 30 years of age. patients with DVT on unusual places.
Part 1: Primary: Patients who are more susceptible to nocebo effects at baseline will have greater clinical pain progression from baseline to one-year follow-up. Secondary 1: Patients who are more resilient to extinction will have greater clinical…
Pelvic organ prolapse (POP) is a common condition in middle aged and elderly women. Approximately 10% of women will have surgery for POP and/or urinary incontinence during their lifetime [3, 4]. POP can occur in the anterior, posterior or apical…
An intervention in hand hygiëne should increase hand hygiëne compliance. An intervention will be implemented at two different moments to see which is more succesful.
Based on the results obtained in our previous study (Ruiter, Kolk, Rietveld, Dijkstra & Lotgering, 2011), we hypothesise that: - The experimental changes to the scenarios and new quantitative scoring procedure of the Amsterdam-Nijmegen…
The aim of this study is to objectively assess 3D and functional outcomes of upper blepharoplasty on periorbital volume, dry eyes, peripheral vision, electrical activity of the frontal muscles and wellbeing in two different surgical techniques. We…
It is expected that the dynamic version of the Wisconsin Card Sorting Test (dWCST) is a valid measure of cognitive learning potential in terms of psychometric properties and construct validity. In terms of feasibility it is anticipated that the…
Rationale: Patients with a psychotic disorder are impaired on many aspects of social functioning and self-management. Consequently, social and emotional isolation is highly prevalent. Furthermore, clinic based (social) skills training tends not to…
Preterm infants are at risk for neurodevelopmental impairment, but also for obesity and risk factors of cardiometabolic diseases. Nutrition in the early neonatal phase and altered early growth might be predisposing these risks. Early body…
Preoperative, intraoperative and postoperative recorded music interventions have been proven effective in reduction of pain and anxiety. Also, recent reviews and meta-analyses provide significant evidence for lower postoperative stress response,…
Implementation of Module CH leads to better tailored care, improved functioning of the user and more efficient use of absorbent incontinence aids.
Exploration of the effects of AAT in adults with an Autism Spectrum Disorder (because this study has an explorative character, there is no hypothesis formulated)
We expect the SPOT-25 to correlate with all three measurement instruments. We expect correlation between the change score in the “hearing function” domain of the translated SPOT-25 and the Glasgow Benefit Inventory to be higher than correlation…
Bariatric surgery leads to vitamin deficiencies and a malabsorptive state that impairs embryonic growth.
Does MS grey matter pathology progress faster in regions with more damage in connected white matter?
Our hypothesis is that MS grey matter pathology, and thereby disease burden and clinical outcome, can be better predicted by looking at damage in the connected white matter in early RRMS patients
Treatment of a subcapital metacarpal fifth fracture with a compression bandage gives the same functional outcome a treatment with paris plaster
VTE risk prediction might be improved by using the modified risk scores.