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We hypothesize that faecal transplantation from a healthy donor can restore the dysbiosis present in UC patients, thereby inducing remission of the chronic inflammation of the colonic mucosa.
Intake of chlorogenic acid and trigonelline reduce postprandial glucose concentrations during an oral glucose tolerance test relative to placebo.
Is CD35, CD21, CD55 associated With Exudative Age-Related Macular Degeneration?
A relative reduction of 50% in the occurence of traveller's diarrhoea.
Extension of SAD PK/PD Model, confirmation of SAD PD effects
The efficacy of reflux inhibitors, which block transient lower esophageal sphincter relaxations (TLESRs), to reduce acid and non-acid exposure may be hampered in the presence of a hiatal hernia, as other mechanisms of reflux become more important.
Folate supplementation improves microcirculatory function in subjects susceptible to microcirculatory dysfunction.
Intra-articular etanercept therapy reduces the clinical signs and symptoms of inflammatory arthritis and improves outcome.
To determine the role of 5-HT2 and 5-HT1A receptors in learning and memory. It is expected that: 1. An acute dose of MDMA will produce impairments on laboratory measures of learning and memory; 2. MDMA-induced memory impairment will be reversed…
A systematic screening and a lifestyle-intervention for pre-diabetes targeted at the Hindustani Surinamese population will prevent or postpone the onset of diabetes mellitus type 2.
This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…
Therapeutic ultrasound will be more effective than placebo ultrasound at reducing pain and improving function in chronic low back pain patients.
To study if a Mediterranean diet (MD) followed by lean donor fecal microbiota transplantation (FMT) has synergistic superior beneficial effects on peripheral insulin sensitivity and (small) intestinal microbiota composition as compared to…
We hypothesize that helium postconditioning reduces ischemia reperfusion injury following an acute myocardial infarction and thereby reduces the size of infarction. Secondly, we hypothesize that this reduction leads to improved myocardial function,…
The addition of inspiratory muscle training to a general exercise training program improves inspiratory muscle strength, exercise capacity, health related quality of life and participation in daily physical activity in patients with COPD suffering…
Doxycycline will ameliorate the vascular condition and inflammatory status in patients with mild to moderate atherosclerotic disease
Hypothesis: infusion of lean donor feces in obese subjects is effective on weight reduction, systemic inflammatory pathways and insulin resistance.
To assess whether individualized feedback of self-reported PrEP medication adherence increases subsequent PrEP use, as measured by tenofovir levels in dried blood spots, in participants using daily PrEP.
(1) SNP will reduce the occurrence of psychomimetic side effects during exposure to low]dose ketamine; (2) SNP will reduce the ketamine]induced increase in blood pressure and cardiac output; (3) SNP is without effect on ketamine]induced pain…
S(+)-ketamine influences resting state fMRI in a dose-dependent fashion.