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The primary objective of the present study is to investigate the effectiveness of the Resource Groups (RG) on patient outcomes compared to care as usual alone for people with severe mental illnesses. It is hypothesized that participation in the RG…
Patients with Type 2 diabetes have been shown to have an increased risk for developing cancer, especially obesity related cancers. There is some evidence that within the class of sulfonylureas there is a difference in cancer risk; gliclazide could…
A Community One Health approach (bringing human and animal health together at the community level) improves disease surveillance efforts by Community Health Workers, health knowledge and behavior and physical health in study populations.
The WALK gait retraining program is more effective to treat patients with symptomatic mild to moderate knee OA and an extension deficit, compared to a standardised treatment protocol based on the KNGF (royal Dutch association of physiotherapists)…
We hypothesize that both cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT) positively affect the primary outcome measure subjective cognitive function compared to enhanced treatment as usual (ETAU). Secondarily,…
We hypothesize that the NIDA is a reliable instrument and that individuals with a clinically diagnosed autistic disorder (AD; DSM-IV) or Asperger’s Disorder (AS; DSM-IV) and/or ASD (DSM-5) report more ASD features (according to the DSM-5) with the…
Both offering choice and using non-controlling language have an independent positive influence on perceived autonomy-support. Not offering choice and using controlling language have an independent positive influence on reactance. Message frame…
The succes of dental implants placed in the augmented maxillary sinus by using a bovine bone mineral (BBM) with some locally harvested AB chips, is superior to, implants placed in augmented sinuses with solely autogenous bone.
The deployment of the pediatric nurse as linking pin between pediatrics and the social domain, shortens the duration of referral to appropriate support for children with (psycho)social problems and it increases the satisfaction of parents and…
Enhanced social knowledge (TASSK), cognition (TUSC) and skills (SSIS + SRS) and improved conversation ability (CASS + CRS)
The study will test the hypothesis that osimertinib treatment result a partial response in 30 % of patients.
MRI can be used as an imaging technique, without the need for sedation and without the exposition to ionizing- radiation, for extensive morphological and dynamic evaluation of the pediatric larynx.
In learning to control myosignals, groups will improve on the metrics that they receive feedback on. Group PatRec will have little improvement in all metrics. Group PatRecFeedback and group Game will have significant improvements in Repeatability…
Adjuvant chemotherapy in stage II CC patients with detectable postoperative ctDNA will lead to a 30% lower risk of disease recurrence within two years compared to standard treatment (regular follow-up).
Although most preterm infants breathe at birth, their respiratory drive is weak and often insufficient to aerate their lungs and establish gas exchange. Extra oxygen is often needed to correct hypoxia, but could then lead to hyperoxia. The optimal…
The pilot RCT has a pre-post study design with the objective to inform the definitive RCT about drop-out rates and estimated effect sizes. We expect a decrease in psychological distress (HSCL-25).
Contaminated duodenoscopes can cause large-scale outbreaks. There is a need for rapid assessment methods to confirm the adequacy of the cleaning phase to improve the quality, safety and logistics of complex flexible endoscope reprocessing. The ATP…
This trial will test the hypothesis whether physical performance and overall well-being of the intervention group supplemented with specialized milk and exercise program will improve compared with a control group without the intervention.