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Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
The hypothesis is that minimal invasive surgical ablation through video assisted thoracoscopic surgey as a primary treatment in patients suffering from (longstanding) persistent atrial fibrillation is superior to transvenous catheter ablation
1) The knowledge of the legal aspects of health care and medical negligence/errors among medical residents is larger in the intervention group than for the control group 2) The flipped classroom model is effective as a teaching method in post…
An expectative management ('watchful waiting') is not inferior regarding the composite of mortality and/or necrotising enterocolitis and/or bronchopulmonary dysplasia in comparison with an early treatment regime in preterm infants with a…
At equi-analgesia respiratory depression from oxycodone is manifold greater compared to Tapentadol
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the online self-management program for patients with Cardiovascular Risk 2. to identify outcome measures most likely to capture potential patient benefit…
The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
A major depressive disorder is a common mental disorder in the general population. It has major influence on functioning in daily life. Depression can lead to cognitive, social and physical problems and has a negative impact on the quality of life.…
The main objective is to assess the effectiveness of a tailored pharmacist intervention for current users of inhaled corticosteroid (ICS) maintenance therapy to improve the disease control compared to a control group with usual care. To tailor the…
Dosages can be lowered succesfully in patients with a stable low disease activity and quality of life. This improves safety and cost-effectiveness.
It is expected that adding the three tailored interventions to the regular Meeting Centers Support programme will better enable attuning the support to the individual variation in needs and preferences of people with dementia and carers and will be…
Training should affect attentional control processes specifically associated with alcohol-related stimuli. As a result, training as an additional treatment on top of CBT should reduce biases to alcohol-associated stimuli which have been linked with…
The aim of this randomized controlled study is to find a difference in clinical AASV recurrence with neoreflux at 1 and 2 years follow-up after Laser crossectomy in comparison with usual EVLA using a 1470 nm radial two rings fibre. (Biolitec)
Snare resection is non-inferior to hysteroscopic morcellation and snare resection is cost-effective.
1. The immediate intervention group will show significantly larger reductions in PCBD, PTSD and MDD at the one week post treatment assessment compared to the one week pretreatment assessment of the delayed intervention group. 2. The treatment effect…
Adaptive Deep Brain Stimulation (DBS) based on neurophysiological biomarkers is equally effective as continuous DBS with less side-effects and energy consumption.
To investigate whether amino acid area under the curve (AUC) and Cmax of product B is equivalent to amino acid AUC and Cmax of product A
OBJECTIVE: To evaluate the immediate and longer-term effects of early cognitive rehabilitation on cognitive performance and self-reported symptoms/functioning in patients with low-grade gliomas and meningiomas, in a prospective randomized trial.…