28 resultaten
Extension of SAD PK/PD Model, confirmation of SAD PD effects
Vaginal atrophy in post-menopausal women results in various vaginal complaints, including dryness. Multi-Gyn LiquiGel is a moisturizing gel with osmo-protectant ingredients. We hypothesize that LiquiGel relieves signs and symptoms of vaginal atrophy…
Systemic eosinophilic inflammation in airway disease (asthma/COPD/asthma-COPD-overlap-syndrome (ACOS)) is associated with small airway inflammation manifesting in dynamic hyperinflation and specific symptoms, which can be reduced by systemic anti-…
H1: Exposure to a mode tailored website as compared to exposure to a standardized website will have a positive effect on distress before the consultation (H1a), communication characteristics during consultation (H1b), distress directly after the…
1. Tapentadol produces effective pain relief in low back pain patients 2. Tapentadol treatment improves/enlarges CPM in patients with CPM defects 3. Tapentadol treatment improves/reduces temporal summation 4. Tapentadol is most efficacious in…
Low back pain is common and associated with a considerable burden to patients and society. There is uncertainty regarding the relative benefit of Paracetamol and Diclofenac and regarding the additional effect of pain medication compared with advice…
Not applicable
We postulate that faecal microbiota transplantation (FMT) from obese donors in patients with cancer can improve satiety (appetite) and subsequently nutritional status. Secondly, FMT might restore the gut barrier function and hence reduce systemic…
The primary objective is to determine whether JWH-018 can be safely administered in healthy volunteers in doses up to 3 mg. Therefore participants will be continuously monitored by a medical doctor and vital signs, laboratory clinical safety and…
It is hypothesized that the outcome of the outcome parameters will be superior for the test product compared to the control product: No difference for the test product compared to the control product is anticipated for the outcome parameter…
- We hypothesize that ingestion of BCAA will increase post-prandial plasma amino acid availability, thereby increasing myofibrillar muscle protein synthesis rates above basal values. - We hypothesize that ingestion of BCKA will increase post-…
Daily treatment with raloxifene 120 milligrams (mg) in addition to antipsychotic treatment improves cognition, reduces psychotic symptoms, increases social and personal functioning, reduces health care costs, as compared to placebo.
- FFR is a valid measurement to determine hemodynamic severity of coronary stenoses in patients with severe aortic stenosis - FFR-guided PCI with concommitant TAVI reduces MACE and revascularisations
Capillary malformations (¡®port-wine stains¡¯) are congenital abnormalities of the capillary vessels of the skin, causing a red or purple color. Laser therapy is currently the only widely accepted treatment option, but treatment response is…
n-3 PUFA supplementation attenuates the loss of skeletal muscle mass during unilateral lower limb immobilization in healthy older men
1. Tapentadol produces effective pain relief 2. Tapentadol treatment improves/enlarges CPM resonses 3. Tapentadol treatment improves/reduces temporal summation responses 4. Tapentadol treatment improves/reduces offset analgesia responses 5.…