960 resultaten
We hypothesize that information from metabolic processes in the paediatric brain tumour and surrounding tissue will help to understand tumour physiology, which will improve diagnosis and treatment evaluation.
The aim of this study is twofold: 1)To assess the effectiveness of a CPG converted into a CDSS, in actually preventing the development of WSLs during orthodontic treatment with fixed appliances compared to usual preventive measures. 2)To evaluate…
To evaluate the cost-effectiveness of therapies for male subfertility.
Part A The main objective of this part of the study is to develop a pharmacokinetic model for [18F]PSMA. Furthermore, use of simplified quantitative methods and procedures will be performed and validated against full quantitative kinetic measures,…
That intermuscular dissection of polyps suspected of deep submucosal invasive carcinoma can result in the radical (R0) excision of > 85% of the carcinomas, and that the risk of local recurrence is below 4%.
With this study we want to test two new modules of a chair specialised for elderly and test whether these new modules improve skin vitality and doe not disturb the users comfort. The new modules apply automatic changes in seating posture after a…
To determine the exposure of IV amoxicillin(-clavulanic acid) in pleural empyema fluid or complicated parapneumonic effusion and to assess the probability of PK/PD target attainment in the pleural fluid of patients diagnosed with pleural empyema or…
The (long term) effectiveness of a school-based universal depression prevention program (“Op Volle Kracht”) will be tested in a Dutch sample of adolescents (aged 12-14 years). It is expected that adolescents who receive the intervention will show…
We hypothesize that the addition of luteal phase support (by the use of exogenous vaginal Progesterone) during MOH/IUI cycles will lead to increased live birth rates. Natural feedback mechanisms and hormone release are affected by artificially…
1. Straatwijzer 2.0 leads to improvements in the knowledge of youths with mild intellectual disabilities (MID) and their parents about the characteristics of their MID, and about the frequently occurring psychiatric disorders ADHD, autism, conduct…
Based on evidence to date, we can assume glycemic and weight benefits from IGlar combined with short-acting GLP-1 RA lixisenatide in T2DM in suboptimal glycemic control, but real-world evidence is needed. Moreover, whether these benefits translate…
The characteristics of snoring sounds could be used to categorize different kinds of snoring sounds, and the treatment effect of OSA/snoring could be evaluated by measuring the characteristics of snoring sounds
Current state of the art myoelectric hand prostheses offer a variety of wrist and hand movement. They were supposed to overcome limitations of myoelctric prostheses which offer one degree of freedom only. However, rejections rates of myoelectric…
In adult Fontan patients, treatment with bosentan, an endothelin receptor antaganost (ERA) lowers the pulmonary vascular resistance, which may result in improvement of the cardiopulmonary circulation and functional capacity.
Hypothesis: Subfertility is influenced by (low) chronic inflammation. Cytokine and microbiome profiling can be substantial in detecting the state of chronic inflammation and may thus help in solving subfertility.
Test the hypothesis that a divisional calculation of heat loss, and incorporation of skin temperature of the extremities during mild cold exposure will indicate an age effect on heat loss between young and elderly. An additional purpose is to test…
Following Moodbuster Lite with guidance provided by a virtual coach or personalised automated motivational support messages leads to higher adherence rates than following Moodbuster Lite unguided.
We expect that the disproportionally strong clinical effects of fingolimod in relapsing remitting multiple sclerosis can be explained by enhanced functional adaptation mechanisms of the brain and that enhanced functional adaptation will be sustained…
The combination of body brace interface pressure measurements and quality of life questionnaires will improve brace treatment in patients with idiopathic scoliosis