176 resultaten
The following hypotheses will be examined: a. patients with multiple sclerosis who become cognitively impaired may experience an increase in pain experience (due to white matter lesions) b. hyperesthesia is known to be predictive of central…
This study aims to implement and evaluate an advance care planning (ACP) intervention for elderly nursing home patients with a limited life expectancy. The intervention consists of ACP discussions integrated with a structured multidisciplinary…
A combination therapy (MDT and TESIs) is effective and cost-effective compared to usual care among herniated nucleus pulpos patients with an indication for a lumbar herniated disc surgery
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
1. The predictive biomarkers for tumor response to immuno modulating therapy will be a combination of adaptive and innate immune status per patient that will be estimated with a tumor biopsy before, 6 weeks after start treatment (optional) and at…
Feasibility and reliability of prehospital triage in patients with thoracic complaints/pain appropriate to a suspicious ACS
The main objective is to investigate whether actigraphy can be used as an objective measure to designate the presence or severity of apathy in patients with schizophrenia. To this end, we will measure activity levels using an accelerometer (i.e.…
The overall hypothesis is that the developed exercise therapy program is feasible, safe and improves cardiorespiratory fitness, functional performance, reduces CV risk factors and disease activity in patients with RA and high CV risk.
There is no formal statistical hypothesis to be tested in this Registry program.
It is hypothesized that the outcome of the primary outcome parameter will be different for the test product compared to the control product.
Preterm infants often require supplemental oxygen to prevent hypoxemia and hyperoxemia. Conditions that have been associated with organ damage and an increased mortality. Newly developed techniques incorporated in the ventilator provide the…
The overall hypothesis is that balance-specific exercise training only improves postural control of sway measured in standing and causes retention of the improved sway behavior and that such behavioral improvements correlate with changes in measures…
Primary objectives 1. Determine prospectively the accuracy of proposed clinical criteria to assess the risk of SA-IE and complicated SAB 2. Determine the diagnostic accuracy of cCT for SA-IE in patients with SAB 3. Determine the diagnostic and…
This study aims to provide a compendium of reference values of absolute aerobic loads of daily activities for people after stroke. Additionally, it will provide insight in the importance of aerobic fitness for daily living. Our study results will…
A goal directed nutritional support can reduce sarcopenia in surgical esophagus patients.
The TOF Cuff NMT monitor is as reliable as the TOF-Watch SX acceleromyograph for perioperative neuromuscular monitoring.
High-dose single-fraction radiotherapy (SBRT) to the primary lung tumor combined with dual immune checkpoint inhibition is safe and feasible and will increase both the systemic response rate to these agents and induce more durable tumor responses…
This phase 0 study will serve to understand the variation in potential pharmacodynamics biomarkers (and methods of analyzing these biomarkers) to be implemented in planned first-in-human single and multiple ascending dose studies with a novel GCase…
We expect the number of seizures to decrease with the introduction of a seizure dog. Besides the effect of seizure dogs on seizure frequency, we expect an impact on participation, well-being, health-related quality of life, healthcare resource use (…
True NC-FET is non-inferior to modified NC-FET in ongoing pregnancy rate after one FET cycle.