205 resultaten
Liraglutide is an effective and safe treatment modality in metformin-treated patients suffering from schizophrenia with anti-psychotic drugs-related diabetes mellitus.
The present mode of (tonic) SCS is accompanied by paraesthesia in the area of stimulation. Recently, a new mode of SCS has been developed which makes it possible to apply spinal cord stimulation without paraesthesias. This mode is called burst…
In view of the poor prognosis of SSc, the presumed autoimmune origin, and the lack of available therapies, this disease is considered suitable for initial investigation of the tolerability and efficacy of anti B-cell therapy. In literature, there…
MIA is a good alternative for the CA, with comparable diagnostic performance. It will lead to an increase in clinical autopsy rates, which have significantly decreased over the last decades in both academic and non-academic medical centers.
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
A positive effect of a Growing Up Milk with added prebiotics or prebiotics and LCPUFA on the intestinal microbiota of toddlers.
Inhibition of the H1 receptor will lead to an improvement of rectal sensitivity, followed by less abdominal symptoms in patients with irritable bowel syndrome.
The expectation of this study is that shorter duration of plaster cast immobilization is beneficial for the patients.
Prevention of respiratory syncytial virus infection using palivizumab in preterm children with gestational age 32-35 weeks will result in decreased incidence of recurrent episodes of wheeze (post-bronchiolitis wheeze).
Extension of SAD PK/PD Model, confirmation of SAD PD effects
Vitamin D supplementation will improve glycemic control in patients with type 2 diabetes melliuts.
It is hypothesized that the behavioral effect (i.e. slower RT and impaired attention) of a non-sedative antihistamine will be apparent in combination with a Pgp-blocker, but will not be apparent when administered alone. This, because when a non-…
The behavioural effects of an antihistamine is apparent in the evening after an evening dose, but will be smaller in the morning after a morning dose condition due to the excessive release of histamine shortly after awaking.
Single dose intranasal dexmedetomidine can be administered safely to elderly people as premedication with respects to hemodynamic changes, irrespective of the concurrent use of betablocking medication
High dose betahistine (48 mg three times per day, tid) is superior to low dose betahistine (8 mg tid) in reducing the frequency of vertigo attacks in patients diagnosed with definite unilateral MD.
the active treatment group has an improvement of at least 10 points of DASH functional outcome more than the placebo group.
1. At baseline, memory performance and neuroendocrine reactions are expected to differ between novice MDMA (< 10 ecstasy exposures) users and heavy/experienced MDMA users (>100 ecstasy exposures). It is hypothesized that heavy MDMA…
The primary aim of the current research project is to establish whether the current Dutch vision screening in children aged 3-6 years old in PYHC can be improved by using plusoptiX, with regard to costs and screening performance.
1. Treatment resistant depression (TRD) is characterized by dopaminergic dysfunction as assessed with a fMRI Pavlovian learning task and [11C]Raclopride PET with amphetamine challenge; 2. Relative to placebo, current serotonergic and noradrenergic…
We hypothesize that dietary nitrate supplementation improves muscle strength and muscle endurance performance.