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By using a surgical safety checklist, the incidence of postoperative complications will decrease.
Despite appropriate antimicrobial therapy and supportive care, septic shock is still a major cause of mortality and morbidity. Within the last decade, a broad body of evidence suggests a potential role for mesenchymal stromal cell (MSC, a…
To investigate the newly developed method to study lung density changes using CT-scan, in a small patient population. The relationship between radiation induced lung density changes and dose distribution/tumor location will be investigated.
The behavioural effects of an antihistamine is apparent in the evening after an evening dose, but will be smaller in the morning after a morning dose condition due to the excessive release of histamine shortly after awaking.
This non-inferiority study specifies as a null hypothesis that ICG enhanced NIRF imaging is inferior in detecting sentinel lymph nodes compared to the current standard treatment (technetium-99m combined with Patent Blue).
Does computer tailored feedback improve the lifestyle of COPD patient?
Objectives: The aim of this study is to investigate the feasibility of a computer-based cognitive training (working memory training) in a relative old and cognitive impaired population of MCI patients. We will examine the effect of this cognitive…
After implementation of the intervention the sustainable workability of teachers and staff in the intervention group will be significantly higher than the sustainable workability of those in the control group, both direclty after intervention and in…
Improvement of favourable outcome by consecuetive treatment of tranexamic acid before aneurysm treatment with switch to acetylsalicylic acid short before start of treatment and continued for two weeks.
Short empirical treatment with a anti-pseudomonal carbapenem in hematology patients with unexplained fever during neutropenia is non-inferior to extended treatment with regard to treatment failure.
Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are important causes of morbidity and mortality. The prevalence and incidence of COPD as well as CHF are still rising. CHF is an important co-morbidity in COPD and vice…
This study aims to test the efficiency and cost-effectiveness of a brief collaborative care intervention, in long-term users (>9months) of antidepressants in the general practice. This intervention will contain a patient-tailored treatment…
Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
Recent data showed for the first time that IgE-ACPA antibodies have a direct biological immune response in mast cells of IgE-ACPA+ RA patients. Subsequently, mast cell targeting agents, such as anti-IgE therapy have rationale for application in RA…
Electrical stimulation of the sympathetic pathways by cervical spinal cord stimulation increases cerebral blood flow.
Compared to standard care, Peer Driven Fellow Care combined with standard care will result in significantly less drop out and improved flow in the social rehabilitation process for homeless people, as well as in significant improvements in…
We hypothesize that a multidisciplinary group-based, self-management intervention is more effective on functioning in daily living and more cost-efficient than the active control group in patients with generalized osteoarthritis (GOA).
We hypothesize that the intervention will prove to be more effective than the control condition in achieving significant body weight loss at 3 months; We expect to observe significant changes in metabolic, psychological and behavioural parameters at…
Dronabinol impairs driving performance in light cannabis users, but not in heavy users, because of tolerance to the impairing effects.
We developed an MRA with integrated accelerometer with which we plan to measure the therapy-effect of the MRA, the compliance and the position of the head of the patient.