299 resultaten
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
We hypothesize that in critically ill patients, measuring the anti-factor-Xa randomly in a 3 to 5 hours timeframe, may introduce a significant variation in the measured anti-factor-Xa and can seriously underestimate the real peak anti-factor-Xa.
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
Exploratory study investigating the efficacy of the currently recommended dosing regimen of ciprofloxacin prophylaxis in patients treated for haematological malignancies.
Fiducial markers placed on endoscopically determined tumor borders are a good surrogate for macroscopic tumor.
We hypothesize that dietary supplementation with seaweed will improve glucose regulation in T2DM patients.
It is an observational study, no null hypothesis has been formulated. The purpose of StEM is to understand the expectations, needs, experiences, choices and decisions of pregnant women and women who recently gave birth in the Netherlands, recording…
High-resolution ultrasound (HRUS) is a quick and cost-effective technique to study the morphology of peripheral nerves. Sonographic characteristics of plexiform neurofibromas and MPNST have been described in the literature. Recently, a pilot study…
Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…
Awake craniotomy improves safety and efficacy during surgery for glioblastoma in eloquent areas
Individual-directed resilience training can reduce chronic stress and prevent burnout among students
Fecal Immunochemical Testing as a Tool to Determine the Need for Colonoscopy in Symptomatic Patients
Using two FIT tests in symptomatic patients prior to colonoscopy can be a useful preselection tool to determine the need for colonoscopy in symptomatic patients.
Reducing the dose in the setting of therapeutic drug monitoring (TDM) does not affect clinical disease activity and safety, while it will reduce costs.
LEND surgery is a (cost)-effective treatment option for patients with Diabetes and lower extremity compression neuropathy, compared to conventional (non-surgical) care.
Chemodenervation by lidocaine of the m. vastus intermedius and the m. rectus femoris improves gait pattern in stroke patients presenting a stiff knee gait.
Paravertebral analgesia is associated with superior quality of recovery by achieving comparable pain control whilst having less side-effects.
The hypothesis is that twins discordant for pregnancy complications display a distinct epigenetic signature in MSCs. This signature contributes to cellular metabolic alterations and is associated with future cardiovascular and neurodevelopmental…
Not applicable
The pharmacokinetics of erlotinib 150mg QD is comparable to the pharmacokinetics erlotinib 75mg + ritonavir 200mg QD.