21 resultaten
1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…
1. A decrease in cocaine use over a three month period in participants who receive AAT training as opposed to VPT training. 2. A change in symptoms involving craving, the urge to use, withdrawals well as stated readiness to change in participants…
The primary objective of the study ”STOP PAIN” is to compare the effect on migraine attack frequency of transcatheter device closure of atrial shunting with a non-closure group in migraine patients suffering severe migraine with aura.
The majority of adolescents in the Netherlands has an inadequate consumption of fruit, vegetables, fibers and an excessive consumption of energy-dense, nutrition-poor foods. Unhealthy diets result in an increased risk of overweight, obesity and…
The aim of the study is to examine the effectiveness of Rock and Water (R&W) and possible moderators and mediators. Effectiveness: - The R&W program will increase students’ socio-emotional adjustment (i.e., psychosocial wellbeing,…
That the laparoscopic approach should be preferred over the open procedure in cases of an elective sigmoid resection for symptomatic diverticulitis.
Standard localized ligations are as feasible as doppler-guided ligations of hemorrhoid arteries.
Dietary fibres and vinegar has been suggested to lower the postprandial blood glucose and insulin response and this may be explained by a delayed gastric emptying.
Preventive group support for 6 to 8 years old children after parental divorce or separation, leads to: - more positive child functioning; - decreased emotional and behavioral problems of participating children; and - increased child wellbeing;
1) Surveillance of patients with a urine test, followed by cystoscopy only when the urine test is positive, results in detection of a the same or a higher number of recurrences and is cost-effective and 2) urine diagnostics contribute to earlier…
The use of SBAR by Community Nurses will improve their selfefficacy and empowerment.
1. Which factors influence electronic cigarette use?
Treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days is non-inferior compared to the standard duration of 10 days of antibiotic therapy with regard to clinical cure rate.
The primary objective of this study is to determine whether treatment with Impella compared with IABP therapy after primary PCI reduces infarct size and results in a higher residual left ventricular ejection fraction in acute anterior wall…
A disease control of 60% is expected and will be clinically relevant with a lower reference bound of 45%.
De belangrijkste onderzoeksvraag voor de huidige studie luidt: -wat is de invloed van het cognitief functioneren op de QoL na een SAB op de lange termijn? De twee secundaire vraagstelling zijn luiden: -is er sprake van een specifiek…
Primair doel• Validatie van de accuratesse van MRI met Vasovist® voor de voorspelling van de klierstatus bij patiënten met een primair rectumcarcinoom gebruikmakend van histopathologisch onderzoek van het resectiepreparaat na chirurgie als Gouden…