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SPECTRE-study

Screening of esophageal cancer can be improved by the optical detection of field cancerization

Modifications in implant features in the TFNA proximal femoral nail as successor of a more conventional intramedullary nail were associated with an increase in fixation failure rate.

No improvement of fixation failure will be found after the introduction of the TFNA

The Severity of maxillofacial trauma in Southern Vietnam: a clinical evaluation of the MFISS and FISS.

In this epidemiologic study a cohort of patients with MFT transferred and/or referred to the National Hospital of Odonto-Stomatology Ho Chi Minh City (NHOS-HCMC), Vietnam, was analyzed following the MFISS and FISS protocol. This study will give a…

The ''CORE-64'' Study.

The sensitivity and specificity of MDCTA for identifying coronary artery stenosis ¡Ý 50% in a patient with suspected coronary artery disease, is of equal quality compared with conventional coronary angiography.

A Phase II study to investigate the effect of Glivec® (imatinib mesylate, formerly known as STI571) in patients with inoperable medullary thyroid carcinoma.

In the pathogenesis of medullary thyroid carcinoma a mutation of the RET thyrosine kinase system plays an essential role. In animal models the thyrosine kinase inhibitor imatinib showed tumor regression. So a Phase-2 study in patients with…

Het opsporen van familieleden met een hogere kans op kanker door het vinden van erfelijke varianten bij mannen met uitgezaaide prostaatkanker in de reguliere gezondheidszorg

Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals

Handscan Registry Leeuwarden

The Handscan is supposed to be more accurate than the current widely used DAS 28, it might be able to measure subclinical disease activity. We want to investigate in which clinical situation, the handscan can be an aide in decision making or can be…

An innovative peer assessment program to improve evidence based practice in physical therapy.

Peer assessment, as a educational guideline implementation strategy, results in more improvement of evidence based reasoning than case based discussion.

BRCA mutations and Ovarian ageing in women applying for in vitro fertilization and preimplantation genetiC diAgnosis

The main hypothesis is that normo-ovulatory women with a deleterious BRCA mutation have lower levels of AMH compared to normal controls, with at least a difference of 0.90 ng/ml, suggesting an effect size of approximately five years in menopausal…

Reversal of oral anticoagulants rivaroxaban and apixaban, by two different dosages of prothrombin complex concentrate (Cofact®).

Reversibility of oral direct factor Xa inhibitors rivaroxaban and apixaban will be the same when a lower dosage of prothrombin complex concentrate (Cofact®) is used. Infusion with doses of 37.5 or 25 units/kg of PCC would be able to reverse the…

Exploratory study on the local dystrophin production restoring effect and safety and tolerability of a single intramuscular dose of antisense oligoribonucleotide PRO051 in Duchenne muscular dystrophy patients.

Antisense oligoribonucleotides inducing exon skipping is a promising approach to restore dystrophin synthesis in patients with Duchenne.

A randomised, controlled, double-blind trial to evaluate intestinal tolerance of a renewed anti-reflux formula in infants with regurgitation.

The investigational anti-reflux formula will be equivalent to the currently marketed control anti-reflux formula with regard to intestinal tolerance during eight weeks in infants with regurgitation.

Impact of an e-learning on the Proximal Serrated Polyp Detection Rate

Endoscopists that received an online training module (December 2017) will increase their proximal serrated polyp detectionrate

An evaluation of organ volume in well-trained strength athletes

1. We hypothesize that well-trained strength athletes (using AAS) will have significantly greater organ volume when compared to well-trained strength athletes (not using AAS) and recreationally active participants (not using AAS). 2. We hypothesize…

Effect of verbal suggestions on the cortisol response to stress

Placebo and nocebo effects affect physiological as well as psychological outcomes through expectancies that can be elicited by, for example, conditioning and verbal suggestions. It has been argued that placebo and nocebo effects induced by…

A Randomised, Double-blind, Controlled Study on the Effect of One Year Administration of a Nutritional Concept on Immunological Status in HIV-1 Positive Adults not on Antiretroviral Therapy

Improving the immunological status of HIV-1 infected adults not on antiretroviral therapy through nutritional support.

Studies on electrophysiologic maturation of the premature brain: small for gestational infants and appropriate for gestational age infants.

Goal: 1. Defining normal electophysiologic matarution in premature infants by quantitative analysing techniques; 2. Identifying circumstances that disturb normal electrophysiologic maturation.

LipiDiDiet Trial.

Dietary management of nutrient deficiencies with the medical food under study has a positive effect on cognitive performance in patients with prodromal Alzheimer's Disease.

The pharmacokinetics of nimodipine, intravenous and orally, in patients with subarachnoidal hemorrhage admitted in the intensive care.

Describing the pharmacokinetics of nimodipine, especially the variability of bio-availability orally administred nimdipine.

Influence of different lipid emulsions on glucose uptake and mitochondrial function in healthy adults

We hypothesized that FFA loading could impair mitochondrial function and that the potency of FFA to disturb mitochondrial function and glucose uptake would depend on the degree of desaturation of the fatty acids infused.