Zoeken naar een onderzoek

A Phase I/II study of Azacitidine (Vidaza®) in pediatric patients with relapsed high-grade pediatric MDS or JMML.

There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…

A study to evaluate the different levels of attention and valence direction for erotic stimuli, in relation to genital and subjective sexual arousal in healthy female subjects and healthy female subjects with Female Sexual Dysfunction.

In the present placebo controlled study we will investigate the influence of valence on attention when viewing visual erotic stimuli. Especially when under the treatment condition of testosterone with sildenafil. In addition, we will investigate the…

Effects of crisis cards/plans for people with psychotic illnesses, facilitated through local patient organisation and through clinician, on the number of crisiscontacts with mental health services and the numer of (cumpulsory) admissions.

N/A

FEmoral BOne fracture study

We expect the protein synthesis rate in (avascular) femoral bone proximal to the fracture to be lower when compared to healthy femoral bone.

Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus?

SLE patients show a decreased humoral immune response to influenza vaccination, as compared to healthy controls. Furthermore the use of immunosuppressives is of influence on vaccination immunogenicity, it has been demonstrated that the use of drugs…

Radiotherapy with or without ibandronate in the treatment of painful bone metastases of prostate cancer.

The purpose of this study is to evaluate the efficacy of oral ibandronate (versus placebo) added to the standard radiotherapy regimen for painful bone metastases to reduce pain, to reduce the need of analgesics, and to reduce skeletal-related events…

Patient satisfaction with Indiveo patient education

Pilot Hypothesis: Patient education for a bronchoscopy with animated medical information is superior compared with written information brochures. Patients who are referred for a bronchoscopy for their diagnosis often experience fear or stress and…

Preimplantation genetic screening (PGS) for aneuploidies in patients with advanced maternal age undergoing in vitro fertilization.

To determine whether IVF/ICSI combined with PGS in patients with advanced maternal age, i.e. women between 35 and 41 years of age, is a cost-effective alternative compared to IVF/ICSI without PGS.

Repetitive Transcranial Magnetic Stimulation (rTMS) treatment for chronic tinnitus.

rTMS suppresses neural circuits using a pulsed magnetic field which temporarily excites or inhibits a certain brain area. It is thought that tinnitus is generated in the brain as a result of functional reorganization of auditory neural pathways and…

Implementation of evidence-based guidelines for appropriate use of ultrasonography in diagnostic breast imaging: the MAMMOED-2 study.

1. To develop (cost-) effective implementation strategies which are feasible in daily practice; 2. To test the guidelines in a multicentre effectiveness trial; 3. To develop general quality indicators with appropriate measuring tools for diagnostic…

Single- or Multiple-occupancy room isolation of patients colonised with ESBL-producing Enterobacteriaceae.

The primary objective of this study is to demonstrate that contact isolation of patients colonised with ESBL-producing Enterobacteriaceae in a multiple-occupancy room is not inferior to contact isolation in a single-occupancy room with respect to…

Asymmetry in Infancy
The effect of pediatric physical therapy on the course of positional preference, deformational plagiocephaly and subsequent developmental delay.

Pediatric physical therapy is effective in asymmetry in infancy, especially to positional preference, deformational plagiocephaly and natural course of asymmetrical motor development, established by plagiocephalometry, range of motion tests and…

Nifedipine versus Atosiban in the treatment of threatened preterm labour: APOSTEL III.

The aim of the study is to compare the effectiveness of tocolysis with Nifedipine or Atosiban in pregnant women with threatened preterm labour with a gestational age between 25 – 34 weeks. We will look at neonatal mortality and morbidity, duration…

(Functional) Magnetic Resonance Imaging of the brain in patients with tinnitus.

The underlying mechanism of tinnitus is tonotopic reorganisation of subcortical auditory areas.

Effects of a nurse coordinated program of lifestyle interventions aimed at reducing the risk of recurrent events in patients who have suffered a heart attack.

A comprehensive multisiciplinary lifestyle intervention program reduces the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.

The efficacy and safety of melatonin treatment in children with ADHD and chronic sleep onset insomnia.

N/A

The Sciatica-PLDD trial.

Percutaneous Laser Disc Decompression is more cost-effective than conventional surgical treatment for lumbar disc herniation and allows faster patient rehabilitation, while long-term functional results are comparable.

Reduced intensity chemotherapy given with and without Imatinib Mesylate in patients >= 60 years considered unfit for standard chemotherapy with previously untreated Acute Myeloid Leukemia (AML) and refractory anemia with excess of Blasts (RAEB, RAEB-T); A randomized phase II study.

The hypothesis to be tested is that the outcome in arm 2 is better than in arm 1.

Blind versus echogeleide radius repositie studie

Leidt echogeleide repositie van een distale radiusfractuur tot minder repositie pogingen in vergelijking met blinde repositie?

Efficacy and safety of ezetimibe in young children with familial hypercholesterolemia.

Ezetimibe monotherapie lowers LDL-C levels, plant sterol levels and inflammatory markers in young children with familial hypercholesterolemia.