17983 resultaten
We will establish the optimal dose chloroprocaine for knee-arthroscopy
The prodrug tamoxifen is metabolized to its most potent metabolite endoxifen by the enzyme CYP2D6. Up to 25% of Caucasians harbour genetic variants leading to a less active CYP2D6. This may lead to lower endoxifen levels and thus lower tamoxifen…
Antibiotics are over-prescribed for lower respiratory tract infection (LRTI) in nursing home (NH) residents due to diagnostic uncertainty. Inappropriate antibiotic use is undesirable both on patient level, considering their exposure to side-effects…
Doxycycline will ameliorate the vascular condition and inflammatory status in patients with mild to moderate atherosclerotic disease
We will test the effect of specific communication interventions and hypothesize that specific interventions will lead to better participant-reported outcomes. We cannot provide detailed information about our hypothesis upfront, as this might…
To assess whether individualized feedback of self-reported PrEP medication adherence increases subsequent PrEP use, as measured by tenofovir levels in dried blood spots, in participants using daily PrEP.
Epidural anesthesia is superiour to general anesthesia considering pain control, blood loss, urine retention, recovery duration and general well being for the patient.
Results of a systematic review showed that lumbar supports are not effective in the primary prevention of low back pain, but there were positive indications for the secondary preventive use of lumbar supports in the reduction of low back pain. In…
Maintenance thalidomide delays the time to progression with 50% in patients who do not progress after > 3 cycles of pemetrexed containing chemotherapy.
Cultured mesenchymal stem cells differentiated into osteoblasts and seeded on scaffolds can induce bone formation.
We hypothesise that there will be no (substantial) differences between both scans for all relevant parameters (e.g. fat mass, lean mass, and bone mineral density) when the same subjects are measured on the same day, under the same conditions.
Fluorescent near-infrared imaging can accurately detect pancreatic cancer non-invasively during a whipple procedure.
There is considerable interlaboratory variation in the grading of dysplasia in duodenal adenomas.
Electrical stimulation on the foot and lower leg will increase the blood flow and thereby the amount of oxygen to the skin. Our overall hypothesis is that this will help to reduce the risk of decubitus on the heel. The specific hypothesis for this…
This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…
1. A screening instrument, consisting of predictive factors, can be used to predict which employees are at risk for sickness absence due to psychosocial health complaints; 2. Coaching is effective in preventing sickness absence and improving general…
Adolescents with emotion regulation problems who followed the Emotion Regulation Training will show improvement on the following items: 1. Symptoms of emotional dysregulation; 2. Positive and negative coping behaviour; 3. Stress symptoms in the…
Compliance with patching therapy for amblyopia can be improved by an educational programme aimed primarily at the child.
The hypothesis is that integrating the exercises of the “The11” in the warming up is beneficial regarding injury incidence, injury severity, corresponding medical costs and/or work absenteeism.