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Impact of clinical decision support on paediatric emergency care.

Evidence based medicine is the standard for current clinical practice. Guidelines and decision rules are developed to support medical decision making. Application of decision rules are supposed to improve efficiency and quality of care by early…

Amlexanox oral adhesive pellicles treats MiRAU.

Amlexanox is not available in China yet or has not been generally accepted in clinical treatment. To explore the effectiveness of amlexanox oral adhesive pellicles in the treatment of minor recurrent aphthous ulcers.

Assessment of a novel strategy to attenuate muscle mass loss during 2 weeks of bed rest

We hypothesize that applying BFR will decrease the loss in leg muscle mass during 2 weeks of bed rest.

The long-term effect of 10 days cold in diabetic patients.

The beneficial effect of cold acclimation on insulin sensitivity is reproducible and the effect wil sustain for a longer period of time. Besides insulin sensitivity, cold acclimation also has beneficial effects on cardiovascular risk factors in type…

Investigating the immune response to COVID-19 vaccination in lung transplantation patients (COVALENT study)

Lung transplantation patients are immunocompromised due to antirejection therapy. The effectivity of the COVID-19 vaccination in this high-risk patient group is completely unknown.

Chronic disease and job retention: the development and evaluation of a training programme for chronically ill employees.

It is hypothesised that participation in the training programme aimed at increasing self-efficacy, establishing work adjustments and improving quality of work, will result in better job retention and fewer sick leave days.

Study evaluating the effects of ana infant formula on physical growth in healthy term infants

The test product supports normal physical growth in healthy term infants

Prevention of lymphedema by therapeutic elastic compression hoses; treatment efficacy.

H0: incidence of lymphedema in hose-group equals non-hose group; H1: incidence of lymphedema in hose group does not equal non-hose group.

Effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy versus Brief Eclectic Psychotherapy (BEP) in the treatment of posttraumatic stress disorder.

In line with a previous pilot study, we hypothesize that EMDR will lead to faster improvements in PTSD symptomatology than BEP and that the effects at the end will be equal.

Comparative roentgen stereophotogrammetry analysis of the Global Tissue Sparing (GTS) stem® compared with uncemented HA coated Taperloc stem.

The implant stability for the GTS is equal to the Taperloc in the initial two years and also thereafter. Focus will be on proximal or distal migration of the centre of the stem, migration of the tip, wear and survival.

Efficacy of genestein as food supplement in patients with the Sanfilippo syndrome (an extension study).

Genestein inhibits the synthesis of heparan sulphate and can possibly slow down disease progression in Sanfilippo Syndrome patients.

Diabetes Lifestyle Intervention Study Slotervaarthospital

In patients with non-insulin dependent type 2 diabetes, intensive, short term physical activity is associated with decreased blood glucose levels and number of cardiovascular complications. In patients who are insulin dependent however, the effects…

Het ontwikkelen van een predictiemodel voor de transitie van acute pijn naar pijn die meer dan 3 maanden persisteert

We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…

DELPHI-trial and DELPHI-SPECT.

Dose-escalation of paroxetine (up to 50 mg/day) does not increase efficacy of treatment of Major Depressive Disorder in patients who did not respond to a 6 week trial of paroxetine in a standard dose (20 mg/day).

MAPLE A
(Melatonin Against PLacebo in Elderly patients).

Hypothesis is that elderly patients, acutely admitted for hip fracture, treated with melatonin for 5 days will experience less delirium than patients treated with placebo.

Breakfast replacement by a low-glycemic index liquid formula in patients with diabetes mellitus type 2.

N/A

Clinical differences between atopic and atopiform dermatitis.

We hypothesize that atopiform dermatitis is a separate entity with specific characteristics, which needs recognition in order to be diagnosed and treated appropriately.

In-vivo validiation of a non-invasive, magnetic resonance-based patient-specific pressure model to determine the severity of common and external iliac artery obstructions, and the need for revascularization.

The one-dimensional personalized pressure model is able to predict the pressure drop over stenotic lessions in the common and external iliac arteries.

A crossover intervention trial to evaluate the impact of rapid on-admission screening in preventing MRSA infection in surgery.

To determine the effect of an early MRSA detection strategy on nosocomial MRSA infections in a cohort of surgical patients at a large teaching hospital.

BRCA mutations and ovarian Ageing in normo-oVulAtory women

The primary hypothesis is that normo-ovulatory women with a BRCA mutation have lower levels of AMH compared to normo-ovulatory BRCA mutation-negative women, with at least a difference of 0.40 ng/ml, suggesting an effect size of three years in…