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The objective is to investigate whether application of a stepwise work-up strategy in primary care patients with uncontrolled hypertension results in better blood pressure control in a cost-effective manner.
The hypothesis of this study is that a difference in mental well-being can be observed after insertion of an LNG-IUD compared to Cu-IUD insertion.
1) Online treatment for nightmares is more effective than a wait-list control group. 2) Efficacy of online treatment is mediated by 'nightmare mastery'
The main hypothesis is that use of Oncokompas will be superior to care as usual to improve patient activation, self-efficacy and quality of life, and it is expected that Oncokompas will improve quality-adjusted life years (QALYs) at acceptable costs…
We hypothesize that increased disease activity (i.e. more inflammation) is associated with an increased risk of developing ID.
The aerobic pre-conditioning will increase muscle perfusion and thereby improve muscle hypertrophy during the subsequent resistance training program.
The use of paracetamol reduces total opioid requirement in the ED and during the first 24 hours.
The use of parenterally administered LEV in neonatal epileptic seizures, detected electrographically, with or without clinical signs, will be safe, and pharmacokinetic and –dynamic properties of the use in neonates will be determined.
Patients with obesity face many health issues such as obstructive sleep apnea (OSA). Prevalence of OSA may be as high as 70% in high-risk populations such as morbidly obese patients undergoing bariatric surgery. Although bariatric surgery itself has…
The absolute bioavailability of oral imatinib (Glivec®) at steady state can be calculated using LC-MS/MS after concomitant administration of a single 100 µg microdose of stable isotope labeled imatinib (imatinib-d8).
The purpose of the Liberté One study is to assess procedural, clinical and angiographic outcomes of the provisional T-stenting approach with the Taxus Liberte stent implanted in complex lesions (with side branch involvement). The Taxus Liberte stent…
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
We hypothesize that anxiety symptoms worsen after follow-up imaging compared to patients baseline anxiety levels.
Addition of alternative tests (TEG/ROTEM® and/or TGA) which reflect the whole hemostatic status of a patient might help recognizing the level of thrombin formation and fibrinolysis and improve care in ECMO patients and potentially reduce the risk of…
Crohn’s disease (CD) is a chronic inflammatory bowel disorder (IBD) with a major impact on quality of life. Mucosal healing is an important treatment outcome to prevent long term complications of the disease. Regulatory M2 type macrophages play a…
By giving high dose, radical, radiotherapy to patients with recurrent lung cancer, the overall survival can be prolonged and local control rate can be increased which can be done with acceptable toxicity for the irradiated normal tissues.
Difference in phenotype between nonbullous and bullous pemphigoid can be explained by gene expression and/or eosinophillic activity in the skin.
Multiple pregancies can be prevented without loss of pregnancy rates by treating couples with manipulated natural cycle IVF or with IVF-eSET plus cryo-cycles instead of standard treatment with intra-uterine insemination and controlled ovarian…
One of the priorities for improving the quality of care is to make care more patient centred. Current acute medical practice focuses strongly on the medical diagnosis and treatment of the medical condition. Many of the conversations in these…
Our hypothesis is that preservation of the pectoral fascia may lead to a decreased seroma formation when compared to fascia removal, and has a beneficial effect on breast reconstructive surgery.