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A 2-Part, Randomized, Double-blind, Double-Dummy, Placebo- and Active Comparator-controlled, Repeat Dose Study to Establish Proof-of-Concept of GRX-917 in Experimentally Induced Panic and to Further Characterize its Repeated Dose Pharmacokinetics and Pharmacodynamics in Healthy Subjects

Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…

Postprandial amino acid uptake kinetics of barley rice proteins

In the current study we aim to measure the postprandial amino acid uptake kinetics of barley rice protein, and compare this to pea protein. A benchmark protein (whey) will be included for comparability of amino acid uptake of different protein…

AmbuLatory Pediatric Asthma CAre: The effect of online monitoring and communication on the quality and quantity of pediatric asthma care.

Evaluate the effect of pediatric asthma eHealth care on the healthcare utilization, asthma outcomes and quality of life.

The impact of milk protein glycation on protein digestion and absorption in healthy young men

To compare the appearance of dietary protein-derived amino acids in plasma after ingestion of a milk protein powder with different levels of protein glycation in healthy young men.

Treating Leg Symptoms in Women with X-linked Adrenoleukodystrophy: A Key to Improving Sleep and Gait Performance

This study has been transitioned to CTIS with ID 2024-518989-27-00 check the CTIS register for the current data. Objective: Primary Aim (PHASE 1):To determine the prevalence of RLS in women with ALD.Secondary Aim (PHASE 2):To determine whether in a…

A single-center, two-part, randomized, open-label, parallel-group, four-sequence, four-treatment, four-period crossover study to investigate the bioequivalence and the effect of food on the pharmacokinetics and safety of single oral doses of two different formulations of RO6868847 in healthy participants

In Part 1 we will investigate and compare to what extent RO6868847 is absorbed, distributed, metabolized, and eliminated from the body of 2 different types of tablet composition. This is done to see if both tablet compositions deliver the study…

Effect of dapaglifozin on serum magnesium in HNF1β patients with renal hypomagnesemia

This study has been transitioned to CTIS with ID 2024-518855-43-00 check the CTIS register for the current data. Primary objective: To evaluate the effect of SGLT2 inhibition with dapagliflozin 10 mg on serum magnesium in diabetic and non-diabetic…

The effects of timed-restricted eating on insulin sensitivity, de novo lipogenesis and liver fat in subjects with obesity and insulin resistance

Primary objectives: To determine the effects of combined isocaloric TRE and meal timing on insulin sensitivity.Secondary objectives: To determine the effects of combined isocaloric time-restricted eating and meal timing on hepatic fat content, de…

Effectiveness of L-serine dietary supplementation in children with a GRIN2B loss-of-function mutation: n-of-1 series

Assess the potential efficay of L-serine dietary supplementation in patients children with a GRIN2B LoS mutation.

Brain and glycemic responses to soft drinks with different sweeteners (SWEETBRAIN)

To determine changes in brain activity in responses to the ingestion of flavored waters sweetened with either the nutritive sugar sucrose or different low-caloric sweeteners.

Vegan Diets: the short-term effects on daily muscle protein synthesis rates as compared to omnivorous diets inOlder adults assessed by D2O.

To investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults.

Promoting immune health by intermittent fasting: a pilot study

To study the direct effects of long-term intermittent fasting on immune cell populations in the blood, combined with analyses of systemic metabolic fitness and inflammatory activation of leukocytes.

Does High Flow Nasal Cannula (HFNC) facilitate CO2-washout during EBUS under procedural sedation?

The objective is to investigate if there is a flow-dependent effect of HFNC on ventilation during an EBUS procedure under procedural sedation in patients with COPD gold class 3-4.

Effect of short-term time restricted eating on innate immunity in patients with coronary artery disease.

To investigate the effect of short term TRE on the innate immune system in patients with a history of myocardial infarction.

Sex differences in the acute effects of guanfacine on activation of the brain stress system in individuals with an alcohol use disorder

The objective of this study is to investigate the role of noradrenergic functioning in sex-specific dysregulation of the brain stress system in individuals with an AUD. This will be done by investigating sex differences in the acute effect of a α2a…

Portable Artificial Pancreas Applied for Youth and Adolescents, PAPAYA 1

The main objective of this study is to determine the performance of the closed-loop system in adolescents with T1DM. Secondary objectives include: • to assess the safety of the closed-loop system; • to determine the time that the closed-loop…

Relative bioavailability study to investigate a potential interaction between dolutegravir (DTG) and tenofovir alafenamide fumarate/emtricitabine (F/TAF) administered as paediatric tablet formulations.

Primary objectives:- To assess the relative bioavailability of TAF and TFV after a single-dose FTC/TAF 3x60/7.5 mg DT (reference TAF) compared to TAF and TFV after a single-dose FTC/TAF 3x 60/7.5mg DT in combination with a single dose of DTG 30mg as…

Phase 1 open-label, crossover study to evaluate the effect of food on the pharmacokinetics and safety of a single oral dose of PTC518 in healthy volunteers.

In this study we will investigate what the effect of food is on how the study compound PTC518 is absorbed, transported, and eliminated from the body.We will also investigate how safe the new compound PTC518 is and how well it is tolerated when it is…

The effect of mealworm protein ingestion on muscle protein synthesis rates during recovery from endurance-type exercise in vivo in humans

The goal of this study is therefore to investigate whether the ingestion of mealworm protein can stimulate muscle protein muscle growth after a single endurance exercise session.

Cue X: a gamified gait-and-balance exercise program for augmented-reality glasses to improve Parkinsonian gait

The primary objective of this clinical feasibility study in people with PD is to evaluate the feasibility and potential efficacy of home-based gamified AR gait-and-balance exercises with Cue X. Secondary objectives of this study are to validate the…