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Language representation in children with 22q11 deletion syndrome and children with Specific Language Impairment

The main objective of this study is to determine the language representation in the brain of children with SLI and 22q11DS.

A double-blind, placebo-controlled, five-way partial crossover study with EVP-6124 and donepezil in the scopolamine challenge model in healthy elderly volunteers

Primary Objectives:• Assess the pharmacokinetic (PK) and pharmacodynamic (PD)/efficacy effects of 3 different single doses of EVP-6124 vs. placebo;• Assess the PK and PD/efficacy effects of the different combinations of 2 doses of donepezil and 3…

A randomized, double blind, placebo-controlled crossover study to investigate the effects of a selective serotonergic reuptake inhibitor on resting state fMRI in heathy volunteers.

We propose to conduct a study in healthy subjects where a serotonergic challenge is given in a placebo-controlled, crossover fashion. Before each challenge, participants will be measured 1 time to define their baseline resting state networks (RSNs)…

Cognitive impairment following cardiac arrest and Target Temperature Management
(A sub-study of the TTM Trial)

Understanding the cognitive disorders in patients who have woken up after a resuscitation and who were treated with a controlled temperature during the ICU treatment

Chronic pain experience in adults with Down syndrome, with and without dementia, and the relationship with cognitive functioning.

The first aim of the present study is to examine whether the pain experience in adults with Down syndrome (without dementia) differs from the pain experience in adults without intellectual disability, after correction for mentale age, comorbidity…

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

Cognitive shifting as a predictor of agression in people with intellectual disabilities and autism spectrum disorders.

This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…

The sense of touch: embodied simulation processes and empathy in Autism Spectrum Disorders

The present study aims at exploring a visuo-tactile mirroring mechanism in patients with autism. Furthermore, the relationship between neural tactile simulation processes, empathic abilities, and symptom severity in the social domain will be…

Correlation of White Matter Fractional Anisotropy Measurements at 3T MRI with Neurocognitive Function in Childhood Cancer Survivors: a Pilot Study

AimThe aim of this study is to determine if WMFA measured by DTI at 3T MRI in cancer survivors is a suitable biomarker in children between 8 -16 years of age for treatment induced neurotoxicity and related neurocognitive deficits.

Imitation, sensitivity for cues, complementary and joint action of children and adolescents with autism spectrum disorder.

The aim of this study is to investigate the hypothesis that persons with ASS may be less capable of 'reading' the behavior of others and because of that they may be less capable of complying to others, leading to social and/or behavioral…

Brain imaging of language function in autistic spectrum disorders

The primary objective of this study is to identify the neural correlates of language functions and, in particular, abnormal pragmatic communication in autistic spectrum disorders.

Dysmorphic Features in Children with Autism Spectrum Disorders

The purpose of the present study is to try to classify autistic children into distinct subgroups, by clinical morphological examination. We mainly want to answer the following questions: 1) Is there an increased prevalence of minor anomalies in…

A randomized, double-blind, double-dummy, placebo-controlled, single dose, 4-way cross-over study of the reversibility of cognitive deficits induced by a nicotinic anti-cholinergic challenge with mecamylamine by a cholinesterase inhibitor and a nicotinic receptor agonist

Primary Objectives • To demonstrate if the impairment of cognitive function caused by mecamylamine administration can be diminished by an nAChR agonist or CEI.• To evaluate to what extent a single dose of 30 mg mecamylamine may cause a more…

A two-part study to evaluate the safety, pharmacokinetics, pharmacodynamics of HTL0009936 in healthy elderly and elderly with below average cognitive functioning.

The objective of the present study is to assess the effect of HTL0009936 on cognitive performance in elderly subjects with below average cognitive function. The oral pharmacokinetics of HTL0009936 shows a significant degree of variability between…

Randomized, double-blind, placebo-controlled, 3-way cross-over study to characterize the pharmacodynamics and pharmacokinetics of single-dose intravenously administered biperiden in healthy elderly male and female subjects

- Characterization of the CNS PD profile of IV administered biperiden- Characterization of the pharmacokinetic profile of IV administered biperiden- To confirm the plasma concentration-effect relationship of biperiden using population PK-PD modeling…

Uncovering molecular mechanisms and neuronal pathways involved in SETBP1 disorder using human cell culture models

Our research aims to establish informative tools in the laboratory for studying the molecular and cellular pathways that are altered in SETBP1 disorder.

Facial dysmorphologies associated with CNV expression in psychiatric illness

Primary objective: To evaluate whether intellectual disability and facial dysmorphology are associated with an increased clinical diagnostic yield of genetic testing among patients with a psychiatric illness.Secondary objective: To investigate the…

Randomized, double-blind, placebo-controlled, two way crossover, single centre study evaluating the acute and chronic effect of clonazepam on cognitive tests and patient-reported outcome measures in patients with ARID1B-related intellectual disability

* To test the hypothesis that clonazepam administration has acute beneficial effects compared to placebo on body sway, adaptive tracking, smooth eye pursuit, tapping frequency and the animal fluency test.* To test the hypothesis that multiple-doses…

Finding suitable clinical endpoints for ARID1B-related intellectual disability

- To determine between-subject and within-subject variability of the study endpoints.- To determine the differences between subjects and healthy controls regarding the study endpoints.- To identify suitable endpoints for future clinical trials in…

Financial decision-making in patients with neurodegenerative disorders - a pilot study.

The primary objectives are to investigate multiple aspects of FDM in patients with AD, MCI and PD compared to healthy controls and to investigate whether FDM problems in these patients can be related to specific neurocognitive dysfunctions. The…