Search for a trial

Postprandial amino acid uptake kinetics of barley rice proteins

In the current study we aim to measure the postprandial amino acid uptake kinetics of barley rice protein, and compare this to pea protein. A benchmark protein (whey) will be included for comparability of amino acid uptake of different protein…

The impact of milk protein glycation on protein digestion and absorption in healthy young men

To compare the appearance of dietary protein-derived amino acids in plasma after ingestion of a milk protein powder with different levels of protein glycation in healthy young men.

Vegan Diets: the short-term effects on daily muscle protein synthesis rates as compared to omnivorous diets inOlder adults assessed by D2O.

To investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults.

Relative bioavailability study to investigate a potential interaction between dolutegravir (DTG) and tenofovir alafenamide fumarate/emtricitabine (F/TAF) administered as paediatric tablet formulations.

Primary objectives:- To assess the relative bioavailability of TAF and TFV after a single-dose FTC/TAF 3x60/7.5 mg DT (reference TAF) compared to TAF and TFV after a single-dose FTC/TAF 3x 60/7.5mg DT in combination with a single dose of DTG 30mg as…

The effect of mealworm protein ingestion on muscle protein synthesis rates during recovery from endurance-type exercise in vivo in humans

The goal of this study is therefore to investigate whether the ingestion of mealworm protein can stimulate muscle protein muscle growth after a single endurance exercise session.

Multicenter study of the performance of Fabian-PRICO for saturation targeting routine use in the NICU

Investigate whether, in a routine clinical environment across a number of centers, the fabian-PRICO can adequately maintain oxygen saturation, with minimal staff intervention.

Difference in digestibility of three protein sources between older and younger adults as measured with the dual tracer method

To determine the difference in amino acid digestibility of milk, sorghum and black beans between older (65-80 years) and younger (20-35 years) adults using the dual tracer method.

Antioxidant and immune effects of vitamin K2

The objective is to obtain insight into a dose-dependent effect of vitamin K2 on oxidative stress and specific markers of the immune system. The primary objective is to investigate the effect of vitamin K2 on oxidative damage to lipids by measuring…

A phase I, open-label, randomized, two period, two-way cross over study to assess the influence of a high-calorie, high fat meal on the bioavailability of a 40 mg extended release PHA 022121 oral formulation

In this study we will investigate the influence of a high-calorie, high-fat meal on the uptake, breakdown, and elimination of the study compound PHA-022121. We will also investigate how safe PHA-022121 is and how well it is tolerated when it is used…

A randomized, placebo-controlled three-way cross-over study to compare the pulsatile intravaginal delivery of oxybutynin versus oral administration.

Primary• To compare the anticholinergic side effects between repeated intravaginal administration of oxybutynin with the vaginal MedRing device and repeated oral administrationSecondary• To explore the pharmacokinetics of oxybutynin and its main…

An N-of-1 double-blind randomized phase 1 trial of the safety and feasibility of (intermittent) hypoxia therapy in Parkinson*s disease

To explore the safety and feasibility of continuous and intermittent hypoxia therapy in PD and the differences of symptom modification of different hypoxia protocols. Secondary outcomes include exploring the responsiveness of subjective and…

A Phase I, two parallel arms, open label, randomized, two period, two-way cross-over study to assess the steady-state pharmacokinetics of a 40 mg PHA-022121 XR tablet administered once daily with the steady-state pharmacokinetics of two 10 mg PHA-022121 IR capsules administered twice daily (Arm 1) and to assess the steady-state pharmacokinetics of 40 mg PHA-022121 XR tablet administered twice daily with the steady-state pharmacokinetics of four 10 mg PHA- 022121 IR capsules administered twice da

In this study we will investigate how quickly and to what extent a formulation of the study compound PHA-022121 is absorbed, transported, and eliminated from the body. There are two compositions of the study compound: one with an extended release…

Effects of N-Acetyl-L-Leucine on Niemann-Pick disease type C (NPC): A Phase III, randomized, placebo-controlled, double-blind, crossover study

This study has been transitioned to CTIS with ID 2023-510278-14-00 check the CTIS register for the current data. Primary Objective:In all jurisdictions except the United States (US), the primary objective is to evaluate the efficacy of N-Acetyl-L-…

A Phase 3, Randomized, Double-Blind Trial of Two Formulations of Setmelanotide (Daily and Weekly) with a Crossover to Open-Label Once Weekly Setmelanotide in Patients with Specific Gene Defects in the Melanocortin-4 Receptor Pathway Who Are Currently on a Stable Dose of the Once Daily Formulation

Primary: To compare the pharmacokinetics (PK) of the once daily (QD) and once weekly (QW) formulations of setmelanotideSecondary Objectives:To assess the safety of the QW formulation of setmelanotide with up to 6 months (26 weeks) of drug…

A randomized, double blind, four-period, six-treatment, double-dummy, placebo controlled, partial-crossover study to explore and compare the ventilatory response to hypercapnia (VRH) of cebranopadol, oxycodone, and placebo in healthy subjects

Primary • To evaluate the effects of cebranopadol and oxycodone on respiratory drive.Secondary• To evaluate the pupil response/ pupillometry following single oral doses of cebranopadol and oxycodone• To evaluate the effects of single oral doses of…

Fully Automated glycemic control with ultrarapid insulin in a bihormonal closed loop System in patients with Type 1 diabetes.

The main objective is to determine the efficacy of Lyumjev in the Inreda AP system. Secondary objectives are: to assess safety, differences in pharmacodynamics and differences in AP-related outcome measures.

The impact of passive heat treatment on glycaemic response during an oral glucose tolerance test in diabetic patients

To assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients.

Effects of recreational nitrous oxide use on psychomotor functioning related to driving performance

Primary Objective: To answer the question: How long after the use of a typical recreational dose of nitrous oxide (4 liters, 100%, bolus administration via inhalation) is there a measurable negative impact on psychomotor functioning?Secondary…

Aronia and Cognitive Fitness: Focus on Brain Insulin-Sensitivity and Vascular Function

The primary objectives are to investigate effects of AME intake on brain vascular function and insulin-sensitivity in cognitive-control brain areas, while we will also evaluate changes in cognitive function (secondary objective).