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Assessment of real life and trained inhalation of Tobramycin Inhalation Powder (TIP) and Tobramycin Inhalation Solution (TIS) TIPTIS study.

Primary objective of the study is to record TIP inhalations on video at home to study the association between inhalation manoeuver and cough. Secondary objectives are: To study the inhalation maneuvers of patients using TIP in the home situation; to…

Long-Term Multi-center Evaluation of E-Poly* and Regenerex* Cementless Acetabular Components: Clinical and Radiographic Outcomes

The purposes of this long-term mutli-center study are: - To compare the long-term (10-year) radiographic and clinical outcomes of new E-Poly* liner in primary total hip arthroplasty with the conventional ArcomXL® polyethylene liner.- To compare the…

The structure of variability in joint coordination of arm movements in children with Developmental Coordination Disorder.

Objective: The aim of this study is to determine how joint coordination of children with DCD aged 5 to 11 years is affected compared to typically developing children when upper extremity movements are performed, i.e. reaching and interception…

The validation of an online platform for older adults to monitor and train their physical and mental capacity and develop proper eating habits

The objective of this study is to investigate the user satisfaction, use, effectiveness and economic outcomes of the PERSSILAA platform for older adults suffering from functional decline in the physical and/or cognitive domain and/or suffering from…

On the effectivity of EMDR in reducing severity and the impact of tinnitus on a patient's life.

The aim of the study is to test whether EMDR is effective to use as an intervention in order to reduce the severity and the burden of tinnitus and to determine whether the alleged effect of treatment is stable.

Age-related changes of the immune system leading to hyporesponsiveness; a major player and predictor for biological behaviour of metastasized melanoma?

To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (>65) treatment naive metastasized melanoma patients at baseline and after treatment.

Posttraumatic osteoarthritis following perilunate dislocations and perilunate fracture dislocations in young patients and the correlation with subjective and objective outcome measures. A descriptive cohort study.

To determine the prevalence of posttraumatic osteoarthritis following a PLD-PLFDs in a cohort of young non-osteoporotic patients and correlation with objective and subjective outcome measures.

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

Implementing Self management using eHealth for monitoring and management after Catheter ablation in the treatment of Atrial fibrillatioN.
A study on the diagnostic accuracy and the effects of eHealth rhythm monitoring on patient related outcomes, clinical management and health outcomes.

Optimise post PVI management using ambulant continuous patient-driven eHealth monitoring after catheter ablation in the treatment of atrial fibrillation.Primary Objective:1) Determine the effect of eHealth on clinical management, outcomes and…

Immunological causes of recurrent miscarriages.

Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?

Study R-FACT
Risk factors for alloimmunization against red blood cell transfusions: a case cohort study

The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…

Closing the preventive care chain for overweight children: evaluation of the implementation of an integrated, locally aligned approach, enforcing primary care.

Get insight in the implementation and effectiveness of the integrated preventive care chain for overweight children in 's-Hertogenbosch. With the results we can optimize the support for overweight children and their parents. .

Medial arterial calcification in patients with hemophilia

The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.

Clinical comparison of the straight lateral approach and the anterior approach to the hip.

The objective of this project is to 1. increase accuracy and reproducibility of the most critical step in hip arthroplasty i.e. cup positioning;2. to alleviate one of the major complications of the straight lateral approach, i.e. abductor…

CD4+ T cells and immune ageing; major players and predictors for disease activity in giant cell arteritis

Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…

Physical performance and protein energy wasting in patients starting with nocturnal hemodialysis
compared to conventional hemodialysis: the DiapriFit study

The aim of this trial is to study if physical performance improves and protein energy wasting decreases in patients who change from conventional hemodialysis to nocturnal hemodialysis, compared to patients who continue their treatment on…

The relationship between visual hallucinations, visual perception and attention in patients with schizophrenia

The primary objective is to investigate if there is a difference in the performance on tasks measuring visual perception and attention between visual hallucinating schizophrenic patients, schizophrenic patients who do not hallucinate and healthy…

Early detection of cardiovascular risk factors after pregnancy complicated by hypertensive disorders or spontaneous preterm birth

We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…

A randomised controlled multicenter trial comparing ultrasound-accelerated catheter-directed thrombolysis combined with standard anticoagulant therapy versus standard anticoagulant therapy alone for acute primary iliofemoral deep vein thrombosis (IFDVT).

Primary Objective: Can catheter directed thrombolytic therapy, for the treatment of primary IFDVT, safely and effectively reduce post thrombotic morbidity after one year?Secondary Objective: Does catheter directed thrombolytic intervention have a…

Executive and social functioning in early- and continuously-treated patients with PKU: A follow-up study 10 years later

The main objective of this study is to examine the executive, social-cognitive, and social functioning and behaviour of 7-30 year old PKU patients in relation to history of treatment and treatment adherence. It is expected that there will be…