36 results
To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
A close correlation has been demonstrated between iron absorption and the capacity of gastric juice to release food iron. At high levels of gastric pH (>3,6), negligible amounts of non-haem iron would be released from dietary components and…
To confirm that loss of gut wall integrity is associated with the development of biliary atresia and to investigate possible hypoxia in the liver/bile ducts in children with biliary atresia using NIRS
Understanding the pathophysiological mechanisms that play a role in liver cirrhosis and its complications. For that aim, we want to study the functional and morphological intestinal epithelial barrier and microbiota of both small and large intestine…
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
To study the association between hypercoagulability and liver fibrosis.
The principal aim of this project is to identify genetic biomarkers involved in susceptibility for drug-induced liver injury in a set of candidate genes (genes relevant to metabolism of drugs and immune system genes).The results of this study will…
The major objectives are to investigate if a prolonged exercise training program can lower the intrahepatic lipid content and can improve the metabolism of the liver in type 2 diabetic patients and patients with non-alcoholic fatty liver disease,…
The most important objectives of this study:1) examine the bacterial translocation as a consequence of elevated intestinal permeability in the morbid obese compared to controls, and to proove this is causes an inflammatory status predisposing IR/…
Hypothetically, in patients with PBC or PSC the FGF-19 production or -response could be altered. The goal of this research is to study the FGF19 production after a standardized oral fat challenge and the effect of this FGF19 production on bile acid…
The aim of this study is to determine whether nose potential difference response is impaired in patients with FIC1-deficiency.
We want to evaluate the relation between intestinal integrity and the constitution of the intestinal microbiota, versus inflammatory and insulin resistance in patients with morbid obesity and patients with a normal weight.
To investigate whether the expression of renal water and sodium transporters in urinary exosomes is different in compensated versus decompensated liver and heart disease.
Assessment of hepatic HSPG*s in NASH associated dyslipidemia in 8 subjects with DM2 associated NASH (insulin resistant, n=8) vs NASH in FHBL (non insulin resistant, n=8) and control subjects (hemochromatosis, n=8)
To demonstrate and compare expression of CCL25 and CCR9+ lymphocytes in peripheral blood and colon of PSC-, PSC/IBD-, IBD-, gastroenteritis patients and controls.
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
The primary aim is to characterize mucosal immune responses in concomitant PSC and IBD. Secondary objectives are (1) to identify phenotype and function of the mucosal immune responses in peripheral blood, liver and intestinal biopsies of patients…