760 results
Our primary objective is to identify the brain networks involved in tremor generation in homogeneous groups of ET patients. In addition we will investigate the differences on a behavioral level during goal-directed movements between ET subgroups and…
The current study will focus on the effects of an intensive programme of exposure of prism adaptation (i.e. daily exposure during two weeks) and compare these to sham adaptation.
The focus of this present study will be to better understand the mechanism of ONS in MICCH. The primary objective of this study is to investigate the putative differences in rCBF at 6 months follow-up compared to baseline between responders of ONS…
- To assess the burden of disease of congenital CMV infection in the Netherlands at the age of 5 to 6 years through the assessment of the occurrence of sensorineural hearing loss due to congenital CMV infection.- To establish the burden of disease…
This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
To investigate motor connectivity in vivo in patients with SMA using MR- techniques for brain imaging.We will investigate connectivity of upper motor neurons in patients with SMA compared to disease controls (patients with myopathic disorders) and…
Primary objective: to assess cortical activity post stroke in a repetitive way to determine cortical involvement in dedicated motor tasks and to relate cortical activity to clinical outcome prospectively after stroke. Secondary objective: to assess…
To compare the feasibility and safety of surface cooling to 34, 34.5, and 35*C, started within 4.5 hours after the onset of acute ischaemic stroke and maintained for 24 hours, in awake patients on a stroke unit.
(1) to establish the neuropsychiatric and personality status (symptoms and impairments) (2) to assess the possible determinants of these symptoms and impairments and (3) to examine the impact of these symptoms and impairments on daily life…
The main objective of this study is to develop a method to identify susceptible pathways of redox metabolism and bioenergetics in peripheral blood cells and induced pluripotent stem cells from patients with PD and DLB.
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The primary objective of this study is to evaluate neurophysiologic changes of the pain centres of the brain (the differences in particular in the thalamus, primary and secondary somatosensory cortex, insula, anterior cingulate cortex and the motor…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
1.To document natural history in this patient group and to establish which factors put patients at risk for an unfavourable outcome. 2.To determine which factors contribute to (reduced) quality of life (QoL) in patients with MMN.3.To investigate the…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…
Primary Objective: Our main goal is to contribute to the identification of an attentional profile of the paediatric TBI population, by analysing the quality and efficiency of alerting, orienting, executive and sustained attentional functioning. This…
The main objective of the study is to investigate whether the strong clinical effects of natalizumab in RRMS can be explained by enhanced functional adaptation mechanisms of the brain and whether enhanced functional reorganisation is sustained over…
Using a variety of methods, we try to determine the dynamics of the chewing movements in typically developing children and children with CP. The methods are, in some degree, complementary to each other. Given the limitations of the methods we need…
With this study we aim to investigate the emotional development, behavior, social behavior, variation in personality traits and intellectual functioning in a group of children who are diagnosed with narcolepsy with of without cataplexie, according…