64 results
Primary objectives:- To investigate possible differences in driving performances between premanifest gene carriers, manifest HD, and control subjects.- To explore if different aspects of cognitive functioning might be a predictor of fitness to drive…
In this study we aim to examine the relationship between certain potential risk factors and the development of Parkinson Disease: environmental exposure to pesticides, exposure to extremely low frequency electromagnetic fields, and the role of…
The aims of this study are the ascertainment, characterization, and longitudinal follow-up of a large cohort of Dutch families segregating Parkinson*s disease, including affected and unaffected first-degree relatives. The cohort will be…
2. OBJECTIVESPrimary Objective: 1. Does conversion tremor show similar abnormal cerebral activation patterns compared to conversion pareses?Secondary Objective:1. Is decreased precuneus activity also present in conversion tremor?
The objective of the present study is to obtain a better understanding of tonic dystonia by quantification of the motor and sensory characteristics of the condition, and to assess the relationship between both these parameters. Specifically, this…
Our primary objective is to identify the brain networks involved in tremor generation in homogeneous groups of ET patients. In addition we will investigate the differences on a behavioral level during goal-directed movements between ET subgroups and…
This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
The main objective of this study is to develop a method to identify susceptible pathways of redox metabolism and bioenergetics in peripheral blood cells and induced pluripotent stem cells from patients with PD and DLB.
The project aim is to optimize existing EEG methods for recording and analyzing EEG data acquired during walking in combination with advanced VR methods for the investigation and rehabilitation of gait and balance impairments. The project aims to…
We hypothesize that PD patients with dopa-responsive and dopa-resistant tremor have different tremor-related brain activity, different inter-regional functional connectivity, and different GABA-ergic tone in the thalamus. Furthermore, we expect that…
Our objective is to perturb neural activity in the parietal-occipital cortex in PD patients (and age-matched control subjects) to determine if the activity contributes to better visually-guided behaviour, but at the same time, to diminished…
• To investigate if FD in CRPS is associated with specific structural and functional changes of the brain.• If so, to find out which of these changes are specific for FD in CRPS, i.e., independent regardless the clinical setting (pain versus…
We aim to determine onset of SCA6 disease more accurate then with the clinical scores and questionnaires that are currently used. We will study motor performance, motor learning behavior, PPI and MRI scans in pre-symptomatic SCA6 patients and…
Key hypothesis of the investigation is that Parkinson*s disease is characterized by deficient entrainment of slow brain oscillations. Our previous work already provides preliminary support for this hypothesis. In order to evaluate to what extent…
A better understanding of the underlying mechanisms of depression in Parkinson's disease will lead to better diagnoses, treatments, and quality of life.
Registry is the core study of the European Huntington*s disease Network (EHDN). The aim of the Registry study is to collect prospective data on the phenotypical characteristics of Huntington's disease (HD) mutation carriers regardless of…
to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.
We expect to isolate system-level neural mechanisms that support compensation for gait and balance in patients with SCA3 following an intensive five-week training programme on a virtual reality treadmill. The goal of the project is to understand…
Our goal is to develop and validate a Movement Diagnostic System (MDS) to accurately locate specific CNS pathological changes in ET, PD-T and DYS, with the use of fMRI and scanner compatible EMG, accelerometry, video, and wrist perturbator.
In recent years, we have identified a Dutch family and performed a large number of studies which have helped us gain insight into the disorder. (MEC protocols 02/223 and 03/140, Dissertation Van Rootselaar, 2006). We want to call on family members…