16 results
The overall aim of this project is to elucidate the interaction between stress and epileptic seizures in childhood epilepsy. The specific aim of this study is to compare the possible differences in stress hormone regulation, hippocampal function and…
To compare the neurotransmitter networks of patients with localisation-related epilepsy patients to those of healthy subjects; To explore the relationship between neurotransmitter, functional and structural network properties, and relate these to…
Identification of a diseased neuronal network characteristic in children with nocturnal epileptiform activity, which can explain language impairment in these children
Primary objective: To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, to analyze and detect genetic risk factors for epilepsy. Secondary…
The main objective of the study is to achieve knowlegde on change in seizure semiology with age in children with partial epilepsy and to improve the understanding in the cause and consequence of this change, in relation to changing functional…
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures…
(1) To asses the influence of P-gp function at the BBB on flumazenil binding to the GABAA-receptor in pharmacoresistant patients with temporal lobe epilepsy (TLE), using PET and [11C]flumazenil as a ligand and tariquidar as P-gp blocker. (2) If we…
In this study we investigate correlations between cognitive impairment as well as response to AED treatment in children with FLE and brain microstructure, function and neuronal connectivity, by using DTI, task related fMRI, and resting state fMRI.
Objectives: In this study we investigate possible correlations between cognitive impairment as well as response to AED treatment in children with FLE and abnormalities in brain micro-structure, function and neuronal connectivity. Therefore, we apply…
Firstly, measurement of the impact of seizures in stroke patients by comparing quality of life, cognitive function, disability, handicap, and mood between stroke patients with and without seizures.Secondly, recording information on treatment of post…
Cognition in patients with Juvenile Myoclonus Epilepsy and their first degree healthy family members
Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
Primary Objectives: 1. To assess the metabolic profile of patients with Dravet syndrome and identify metabolic variations that contribute to the pathophysiology of seizures and developmental delaySecondary Objectives:2. To assess the association…
1) To study cognition in children with absence epilepsy and the development of functional brain organization.2) To find prognostic factors in terms of clinical, 24h-video-EEG or/and MRI characteristics for cognitive deterioration and/or poor seizure…
To elucidate the role of cortical inhibition in PGES (pilot).
Rationale and Objective: Up till now, neuronal correlates of post-stroke epilepsy and the comorbid cognitive dysfunction in patients are largely unknown. Therefore, the aim of this study is to unravel imaging biomarkers of post-stroke epilepsy. We…