29 results
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
1.To document natural history in this patient group and to establish which factors put patients at risk for an unfavourable outcome. 2.To determine which factors contribute to (reduced) quality of life (QoL) in patients with MMN.3.To investigate the…
Our primary objective is to study the cellular immune response in CIDP during different stages of disease activity and to explore their role as a biomarker for treatment response and disease activity in patients with CIDP.
To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
To clarify the aetiology of CTS and prognostic factors for the development of CTS.
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
As none of the proposed experimental conditions have been executed with chronic pain patients, our main objective is to determine the sensitivity of the experimental conditions. Besides, we investigate the attention-bias for pain signals that…
The primary objective is to determine whether the DC/B-cell response to C. jejuni LOS differs in (ex-)patients with C. jejuni-related GBS compared to healthy controls. Secondly, we aim to define the variation in DC/B-cell response to C. jejuni LOS…
To obtain robust evidence for activity-dependent CB and depolarizing CB in CIDP or MMN. This may reveal specific mechanisms of axon loss and provide a rationale for additional treatment aimed at prevention of irreversible axon loss.
To investigate whether propriocepsis or reflexes are present after nerve reconstruction
The objective of this study is to test the hypothesis that in patients with inflammatory neuropathies and conduction blocks, corticosteroid treatment leads to:1. Hyperpolarization and reduced excitability of motor axons. 2. An increase of the number…
To clearify the etiology of CTS and prognostic factors for the development of CTS.
1)To determine the contribution of reversible dysfunction of nerve terminals to weakness 2) To identify electrophysiological patterns that improve classification of GBS patients, and that discriminate between patients with good and poor prognosis 3…
Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…
To clarify the pathophysiological substrates of residual weakness and fatigue
The aim of the study is to describe the incidence and characteristics of CRPS in the Dutch population. Also will be investigated which factor are associated with the ocurrence of the disease.
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
Primary Objective: To study whether nocturnal symptoms of CTS depend on wrist position and, if so, on which position. Identifying which wrist position aggravates CTS could help design a more effective splint. Secondary Objective: To study whether…