275 results
The primary objective of this study is:to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and healthy controls.The secondary…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
The study objectives are to measure the impact of swimming in chlorinated water on the upper and lower airways of children with and without *doctors diagnosed asthma* by means of the following methods: 1.Tympanometry after otoscopy 2.Airway…
The objective of this study is to test our hypothesis:Hypothesis - We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive *fingerprint* based on the combination of:…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
Is there an association between involvement in incidents with airway irritants and respiratory effects in first responders.
Besides more basic research into which RNA-binding proteins and microRNAs regulate the expression of inflammatory mediators in airway epithelial cells, we will also assess these proteins and microRNAs in airway epithelial cells from patients with…
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
To determine exercised-induced bronchoconstriction with an objective and standardized exercise test for infants and young children (3-6 years); to compare resistance and compliance in wheezy children and healthy children before and after exercise-…
The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…
To investigate the role of different ADAMs (e.g. ADAM10 and ADAM17) in cigarette smoke extract (CSE)-induced production of inflammatory parameters (TGF-* shedding, MUC5AC and IL-8) in primary epithelial cells and compare the effects in cells derived…
The major research objectives are (1) to prove that PBMCs isolated from asthma patients are indeed characterized by a Th2 phenotype and (2) that this disturbed balance can be restored by adding plant sterols or stanols during in vitro culturing and…
Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…
The aim of the study is first to develop knowledge concerning underlying mechanisms that can explain the relationship between obesity and asthma.
Primary endpoint:Measuring lymphocyte response in patients with suspected pulmonary bird fanciers lung by ELISPOT technique.
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…
Primary objective:Study A: Development, validation and reproducibility of a method to assess arm activity.Study B: Investigate the association between muscle effort and arm use during a series of daily activities in COPD patients and healthy age…
To compare the levels of vitamin D in subjects with non-atopic asthma to those in subjects with atopic asthma and those in healthy non-atopic subjects