262 results
Primary Objective: To measure cortical spreading depression with full-band EEG during the migraine attack at patients aged 4 years or older. Secondary Objective(s): -To explore (additional) signal analysis techniques for detecting CSDs or infra slow…
The first objective of this study is to gain insight in which neurocognitive and neurobiological processes underlie the development of externalizing behavior (in specific aggressive behavior) in the first two years of life. The second objective is…
Answering the question if there are any associations between hormonal status in adolescence on the one hand, and immunological reactivity and pharmacodynamics on the other hand; and if such associations can explain the more rapid deterioration of…
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
To determine the reproducibility and validity of specific outcome measures for skeletal and respiratory fatigability in subjects with SMA.
Hypothesis: Early life stress is associated with increased caloric intake and subsequent obesity in later life, which may be mediated by (a combination of) decreased neural cognitive control over food intake, decreased neural food reward…
Primary ObjectiveTo assess in 20 adolescents with anorexia nervosa the cognitive flexibility in response to two computerised category learning tasks and compare these results to a age and gender matched control group. Task one will present pictures…
Here we will generate iPS cells from patients with genetic neurodevelopmental disorders and (related) healthy control individuals, that can be used to generate in vitro disease models to further study the mechanisms behind these disorders.
We hypothesise that, in comparison with the current practice of aggressive nutritional support, tolerating caloric deficits early during critical illness in critically ill children has *carry-over* effects, through epigenetic changes, that improve…
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
The primary objective of CDfuture is to provide duodenal biopsies of patients with and without CD, and venous blood samples, to continue CD research as described above.
The aim of the study is to investigate the neurobiology of Conduct Disorder (CD) in female and male children and adolescents, and examine for sex differences in the phenotype (clinical presentation) of CD, and the relationships between CD and…
1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…
The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…
Idenification of new Hirschsprung's disease associated genes.
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
1. Examine the physiological, endocrinological and neural differences between children with PTSD and without PTSD2. Examine if neurobiological treatment effects of TF-CBT and EMDR differ and if so how3. Examine if neurobiological treatment effects…
The current study aims to fill some of this gap by comparing family functioning in young people with MUPS to family functioning in young people with medically explained physical complaints and healthy young adolescents. Other family factors that are…
The two primary objectives of this study are:(1) to explore whether UHR in adolescence is associated with neurobiological differences at baseline and/or changes in the course of 4-8 year of follow-up as measured using MR-techniques and compared with…
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…