24 results
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
The objectives of this study is to determine the recovery and survival of platelet concentrates; in the first phase, a comparison will be made for platelet concentrates in plasma stored for 2-3 days versus those stored for 6-7 days; in the second…
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
To determine and compare PK profiles of two of the most used ROOs in cancer patients: one intranasal fentanyl formulation (INFC, Instanyl®) and one sublingual fentanyl formulation (SLF, Abstral®).
the aim of this study is to compare the impact of an early-CR within 48 hrs. after PPCI to a late complete revascularization >2 weeks after PPCI on LV remodelling in patients with STEMI and multi-vessel disease.
To determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity (MSNA) in patients with metabolic syndrome at 3 months after renal denervation.
The aim of this study is to explore the efficacy, effectivity and costeffectivity of financial incentives for the promotion of physical activity in the health care setting.
The objective of this study is to evaluate safety and blood pressure response after renal denervation in patients with uncontrolled hypertension on three standard antihypertensive medications compared to a sham-controlled population. These data, in…
To measure the quality of peripheral visual field in healthy volunteers and the effect of different corrective lenses on the peripheral visual field.
Primary Objective: The main aim of this study is to investigate if EMDR diminishes negative associations with fatigue in CFS-patients who follow CBT.Secondary Objective(s): Second, we will investigate if EMDR strengthens the belief of the patient…
The objective of this proposal is to investigate if duloxetine is effective as a third choice pain medication for treating chronic pain in OA compared to usual care. Furthermore, we will assess the cost-effectiveness of duloxetine treatment and if…
Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.
The search for correlations between components of the diet and the group has experienced a hip fracture. These findings are compared with healthy elderly. The results can contribute to nutrition -focused interventions in future studies .
MRI vessel wall characteristics of peripheral arteries and arterial stiffness in hemophilia patients
The primary objective is to analyze and compare morphological (media- thickness) and functional (stiffness) vessel wall parameters of peripheral arteries between hemophilia patients with an ankle- brachial index >= 1.3 and hemophilia patients…
Identify DNA methylation markers suitable for sensitive and specific plasma-based detection of advanced colorectal adenomas.
The two main objectives are the identification of molecular and clinical signatures that can serve as diagnostic and/or severity-of-disease markers for AD in flare and remission. And the identification of key immunological and molecular pathways…
The objective of this study is to evaluate safety and blood pressure response after renal denervation in patients with uncontrolled hypertension compared to a sham-controlled population, in the absence of antihypertensive medications. These data,…
To establish if a short period of exergame balance training will affect postural control and/or balance recovery reactions in older adults.
We aim to obtain more insight in the pathogenesis of DS. This replication study will focus on molecular determinants suchs as methylation and gene transcription. In addition, we will collect phenotypic information and link this with information…