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To determine early and subtle MRI changes in premanifest and early manifest HD patients which distinguish them from the healthy population. This includes both structural/quantitative MRI data and MRI-signs of blood-brain barrier (BBB) breakdown. And…
The objective of this study is to investigate the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or…
To determine the value of and generate the clinical evidence for routine application of Whole Genome Sequencing (WGS)-based diagnostics and targeted therapy guidance for glioblastoma patients at time of first recurrence.
Primary objective: To examine whether the use of CDSS-OPTIMED, a personalized medication advice to attending physicians of patients in the last phase of life, contributes to patients* quality of life. Secondary objectives: To evaluate the effect of…
Part A:- Evaluate the safety of increasing doses of a single dose continuous DMT infusion over 90 minutes in healthy smokers - Characterize the pharmacokinetics of a single dose DMT administered continuously over 90 minutes in healthy smokers -…
The purpose of this study is to expand the so far limited research on the effectiveness of ImRs in the treatment of OCS. The primary objective is to investigate whether the application of ImRs, after previous outpatient ERP treatment, leads to…
The aim of this study is two-fold:1.To elucidate the role of neuroinflammation in FTLD2.To identify biomarkers to predict and monitor disease progression in FTLD3.To differentiate FTLD-TDP from FTLD-tau during life using biomarkers for…
The overall aim of the study is to develop innovative minimally invasive monitoring techniques that can identify lung inflammation in pwCF when using highly effective modulators, compared to patients whom are not eligible for CFTR modulators (…
The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…
This study has been transitioned to CTIS with ID 2024-517258-85-00 check the CTIS register for the current data. The primary objective of this study is to determine the feasibility and safety of quantitative fluorescence endoscopy using the…
The main objective of this study is to examine whether Virtual Reality Aggression Training - Intellectual Disability (VRAPT-ID) is effective in reducing ag gressive behavior over time among inpatient forensic psychiatric patients, specifically those…
Primary: To determine the contractile strength and the structure of single muscle fibers isolated from biopsies of the diaphragm and lateral abdominal muscles from mechanically-ventilated patients. Secondary: (i)To elucidate the molecular mechanisms…
Primary Objectives: 1. To investigate the nature and extent of persistent fatigue and cognitive complaints 2. To investigate the impact of persistent complaints on health-related quality of life and health care consumption3. To identify risk factors…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…
To accomplish this aim we will address the following objectives:1. Define kidney disease heterogeneity within and between families carrying heterozygous COL4A3/COL4A4 pathogenic variants and evaluate hearing loss as non-renal phenotype;2. Analyze…
The primary objectives of this study are to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA), as measured by change in Children's Hospital of Philadelphia…
Primary Objective: To evaluate the safety of high-dose rifampicin (35 mg/kg/d) supplemented with standard doses of isoniazid, pyrazinamide, and ethambutol for 8 weeks in adult subjects with pulmonary or extrapulmonary DS-TB belonging to difficult to…
The objective of this study is three-fold: 1) Assess measurement settings and develop the data processing chain to detect contrast signals in the left-ventricular wall with contrast-enhanced high-frame rate echocardiography. Determine whether this…
Our objective is to safely increase the visit interval to 6 months in JIA patients with stable disease. The skipped 3-month visit isreplaced by a self-evaluation via e-mail by EQ-5D-5L-Y and JAMAR questionnaires that will be send via Castor EDC.…
To investigate te efficacy and the toxicity of protone radiation of thymomas and thymic carcinomas.