40 results
This study compares the efficacy of guided self-help CBT-E with to screen-to-screen CBT-E in terms of robust remission at end of treatment and during follow up. Robust remission will be defined as eating disorder pathology below a clinical cut-off…
To investigate neural response patterns to visually and orally presented palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in AN patients and matched healthy controls (HC). This will be investigated through 1 study with 2…
We will use a conditioning paradigm to experimentally investigate how individuals with AN compared to healthy controls (HCs) avoid disorder-specific, as well as generally aversive and pleasant outcomes and to what extent avoidance behaviors return…
The first aim of this research is to identify predictors of one-year treatment response after initial clinical diagnosis in a large sample of adolescent girls with AN. The results of this study could allow us to assess different treatment strategies…
The objective of the study is to determine the difference in brain responses after consumption of processed and unprocessed food between healthy lean subjects with a *normal* eating pattern with that of Binge Eating Disorder (BED) patients, who are…
It will be investigated whether a new form of exposure therapy, aiming at the reduction of anxiety by the disconfirmation of expectancies and learning of new inhibitory associations will lead to less AN symptoms, better acceptance of weight gain and…
The aim of this study is to gain knowledge about how disgust may contribute to the eating disorder Anorexia Nervosa (AN). Part 1 aims to test a theoretical model on the relationship between disgust propensity, disgust sensitivity, self-disgust and…
We aim to investigate the efficacy of a novel eating disorder prevention program, the Diabetes Body Project, specifically targeting young females T1D. Firstly, we will test the hypothesis that Diabetes Body Project will produce significantly greater…
EDGI aims to enhance the understanding of the underlying biology and genetic architecture of the different eating disorders. Therefore GWA analyses (both within and cross disorder analyses) will be performed in the EDGI samples combined with the PGC…
The primary objective of the current study is to investigate whether self-disgust is heightened in patients with AN. If this indeed is the case, this would provide important leads to improve existing treatment options for AN.
Objective: In this study we propose elucidating the pharmacokinetics of olanzapine in AN patients, to optimize the dosing strategy, to the extent of increasing the efficacy and reducing the risk of side effects. To this end, we will assess the…
The current study investigates the effectiveness of an intervention that focusses on the adaptive emotion regulation strategy cognitive reappraisal for people with EDs in the reduction of anxiety. This intervention will be compared to a control task…
The current study aims to examine the influence of suppression as an emotion regulation strategy on inhibition in patients with Anorexia Nervosa restrictive type (AN-R), Anorexia Nervosa binge purge type (AN-BP), Bulimia Nervosa (BN), and Binge…
Objective: The primary objective of this study is to investigate interoceptive abilities in adolescents with AN. To capture the multidimensional perspective, interoceptive abilities will be studied on an accuracy, sensibility and awareness level.…
The primary objective of this study is investigating whether AN patients and healthy controls differ in how they estimate the size of their shoulders, waist, and hips before and after induction of the OBI. We will specifically investigate whether…
GSH CBT-E is an internet-based guided self-help intervention. Objective of this study is to investigate the effectiveness of GSH CBT-E in comparison with a waiting list condition on frequency of binge eating (BE). Secondary objective is to measure…
To study the differences in MI between short-term ill adolescents with AN (< illness duration 1 year) and patients who started their illness in adolescence and have been ill for at least 5 years consecutively and with healthy controls. A…
Bariatric surgery does not directly target the underlying psychological factors that potentially contribute to the development and maintenance of obesity (Cassin et al., 2013). Despite some psychosocial factors predicting postoperative weight loss…
Deep Brain Stimulation in Patients with Chronic Treatment Refractory Anorexia Nervosa: a Pilot Study
The aims of this research project are:1) to establish the efficacy and feasibility of DBS as a last resort treatment in patients with chronic, treatment refractory AN. 2) to associate the efficacy and functional effects of DBS in patients with…
Primary Objective: a) piloting the intervention- to identify whether DBI is feasible and acceptable (tolerability, appropriateness, usefulness) being studied from both the perspective of study participants, the research team and clinicians, and…