143 results
The overall aim of the study is to characterize the underlying mechanisms of the development of walking in children with CP, through the combined measurement of electromyography (EMG) and electroencephalography (EEG). We will in particular identify…
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
To validate SAI as a measure for cholinergic innervation by relating SAI directly to [18F]FEOBV PET imaging. The secundary aims are as follows: - To assess the correlation between SAI and cognitive functioning, motor symptoms, RBD, walking speed,…
Our primary objectives are to study: 1) differences in the brain*s sensitivity to the effects of light on emotional processing in people with PD and people with depressive symptoms compared with healthy controls 2) whether different spectrum of…
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…
To develop and validate a probabilistic subcortical atlas of a PD population using 7Tesla MRI, and to validate this atlas for use on 3T MRI data.
The present study aims at examining the effects of DBS on speaking. We will test participants performing a verbal fluency task but also producing spontaneous language and performing a language task that is dependent on a brain area targeted by DBS.
The primary objective is to develop algorithms that define digital biomarkers for disease progression in Progressive Supranuclear Palsy patients. The biomarkers, when developed systematically, can eventually serve as primary or secondary clinical…
Primary Objective: to investigate the prevalence of bruxism and TMD in PD patients through objective measurements.Secondary Objectives: to identify factors associated with the presence of TMD or bruxism in a PD population.
The aim of this study is to better understand the relation between cognition, sensory functions and motor control for speech in older age. Thereby, we strive for improved speech-based discrimination of typical aging from neurodegenerative declines.
The primary objective of this study is:* To investigate whether a two-weeks intervention with cerebellar anodal tDCS could improve ataxia severity in SCA3 patients compared to sham stimulation.Secondary objectives of this study are:* To investigate…
The objective of this study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients .Primary research question:…
We aim to study the cost-effectiveness of specialized nursing care provided by a Parkinson Disease Nurse Specialist (PDNS) as compared to no PDNS care for patients with Parkinson's disease in all disease stages.We will also perform a subgroup…
In preparation for future clinical studies using LRRK2 kinase inhibitors currently in development, the current study aims to characterize several potential pharmacodynamic markers of LRRK2 kinase inhibition and patient stratification. In particular…
The main objective of the study is to quantify functional gait abilities in children with DCD. The second goal is to evaluate whether their gait abilities can be improved by training.
Visualising subdivisions of the Subthalamic Nucleus in Parkinson*s Disease with Ultra-High Field MRI
The current study aims to go further than the previous METC application of B. Plantinga (2014). In addition to providing optimized structural delineations of the STN via the increased contrast offered by 7T MRI, the existence of structural…
The objective of this study is twofold. The first objective is to study the effectiveness of implicit motor learning on walking speed in clients after stroke in daily practice. The second objective is to determine the technology acceptance,…
The main objective of this study is to validate a VR foot pedalling paradigm to study visual cueing and freezing of gait in patients with PD-FOG, to allow for its use in future neuroimaging studies. The secondary objective is to assess the influence…
The goal of this study is to collect pilot data using the neuromelanin sensitive MRI sequence in patients with schizophrenia of psychoses, patients with Parkinson's disease and healthy controls. These pilot data will be used for grant…
To investigate the timing and coordination of speech articulation of PD patients. This information will lead to a better understanding of dysarthria and will ultimately aid speech therapy.